Pinocembrin Protects Human Brain Microvascular Endothelial Cells against Fibrillar Amyloid-
Injury by Suppressing the MAPK/NF-
B Inflammatory Pathways
Cytoprotective effects of pinocembrin on hBMECs against fAβ 1–40-induced toxicity. (a) Pinocembrin increases cell viability as evaluated by MTS assay. (b) Pinocembrin decreases the levels of extracellular LDH released from hBMECs against fAβ 1–40-induced toxicity. (c) Representative images of nuclei stained by Hoechst 33342. Pinocembrin attenuates nuclear damage in hBMECs in the presence of fAβ 1–40 (×20). (d) Pinocembrin inhibits nuclear mean fluorescence intensity in hBMECs against fAβ 1–40-induced toxicity. Data are expressed as means ± SEM, , versus control, , , versus fAβ 1–40.