Pinocembrin Protects Human Brain Microvascular Endothelial Cells against Fibrillar Amyloid-
Injury by Suppressing the MAPK/NF-
B Inflammatory Pathways
Effects of pinocembrin on MAPK pathways of hBMECs against fAβ 1–40-induced toxicity. (a) Images of phosphor-p38, phosphor-MK2, phosphor-SAPK/JNK, phosphor-c-Jun, and phosphor-ERK1/2 were acquired on the ArrayScan HCS Reader using the Cytoplasm to Nucleus Translocation BioApplication (×20). (b), (c), and (e) Values of Mean_CircRingAvgIntenDiff describe the capacity translocation of cytosolic phospho-p38, phospho-SAPK/JNK, and phospho-ERK1/2 to the nucleus and nuclear phospho-MK2 to the cytoplasm. (d) Nuclear average fluorescence intensity illustrates the expression of phosphor-c-Jun. Data are expressed as means ± SEM, , versus control, , , versus fAβ 1–40.