Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice

Table 1

Effects of pretreatment with different doses of melatonin on serum toxicity marker enzymes along with CP administration.

Groups	Marker enzymes^a
	Serum AST (IU/L)	Serum ALT (IU/L)	Serum ALP (IU/L)
Control	42.37 ± 1.46	31.39 ± 1.48	52.28 ± 1.29
CP	123.78 ± 4.24^b	96.18 ± 2.07^b	185.86 ± 5.37^b
Melatonin 2.5 mg/kg + CP	112.67 ± 3.38^c	67.61 ± 1.19^f	121.97 ± 0.35^c
Melatonin 5 mg/kg + CP	73.54 ± 2.48^d	54.32 ± 2.17^d	87.29 ± 2.45^d
Melatonin 10 mg/kg + CP	63.27 ± 2.61^d	32.47 ± 2.61^e	61.05 ± 3.31^d
Melatonin 20 mg/kg + CP	42.18 ± 2.09^e	31.19 ± 2.28^e	54.38 ± 4.91^d

CP: cyclophosphamide; ALP: alkaline phosphatase; ALT: alanine transaminase; AST: aspartate transaminase.
^aValues are the mean ± standard deviation for each group of 5 mice. ^bP < 0.001 compared to the control; ^cno significant difference compared to the control group; ^dP < 0.01 compared with the CP-treated group; ^eP < 0.001 compared with the CP-treated group; ^fP < 0.05 compared with the CP-treated group.
The data were analyzed with one-way ANOVA and Tukey's HSD test.