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BioMed Research International
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2014
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Article
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Tab 2
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Research Article
Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice
Table 2
The results of semiquantitative histopathological examination of the liver. Protection by melatonin at different doses against CP-induced tissue damage.
Factors/grades
Groups
Control
CP 200 mg/kg
Melatonin 2.5 mg/kg + CP
Melatonin 5 mg/kg + CP
Melatonin 10 mg/kg + CP
Melatonin 20 mg/kg + CP
Inflammatory and hemorrhage in portal area
Grade 0
+
Grade 1
+
Grade 2
Grade 3
+
+
+
Grade 4
+
Hepatocellular necrosis
Grade 0
+
Grade 1
+
Grade 2
+
+
+
Grade 3
+
Grade 4
Lymphocytic inflammatory infiltrations
Grade 0
+
Grade 1
+
Grade 2
+
Grade 3
+
+
Grade 4
+