Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice

Table 2

The results of semiquantitative histopathological examination of the liver. Protection by melatonin at different doses against CP-induced tissue damage.

Factors/grades	Groups
	Control	CP 200 mg/kg	Melatonin 2.5 mg/kg + CP	Melatonin 5 mg/kg + CP	Melatonin 10 mg/kg + CP	Melatonin 20 mg/kg + CP
Inflammatory and hemorrhage in portal area
Grade 0	+
Grade 1						+
Grade 2
Grade 3			+	+	+
Grade 4		+
Hepatocellular necrosis
Grade 0	+
Grade 1						+
Grade 2			+	+	+
Grade 3		+
Grade 4
Lymphocytic inflammatory infiltrations
Grade 0	+
Grade 1						+
Grade 2					+
Grade 3			+	+
Grade 4		+