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BioMed Research International
Volume 2014, Article ID 471082, 5 pages
Research Article

Scattering Coefficients of Mice Organs Categorized Pathologically by Spectral Domain Optical Coherence Tomography

1Institute of Modern Optics, Key Laboratory of Optical Information Science & Technology, Ministry of Education of China, Nankai University, Tianjin 300071, China
2Nankai University Affiliated Hospital, Tianjin 300121, China
3Department of Bioengineering and COMSET, Clemson University, Clemson, SC 29634, USA
4Institute of Micro & Nano Optics, Shenzhen University, Shenzhen 518060, China

Received 22 January 2014; Revised 19 March 2014; Accepted 19 March 2014; Published 13 April 2014

Academic Editor: Shiwu Zhang

Copyright © 2014 Q. Q. Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Differences in tissue density cause a variety of scattering coefficients. To quantify optical coherence tomography (OCT) images for diagnosis, the tissue's scattering coefficient is estimated by curve fitting the OCT signals to a confocal single backscattering mode. The results from a group of 30 mice show that the scattering coefficients of bone, skin, liver, brain, testis, and spleen can be categorized into three groups: a scattering coefficient between 1.947 and 2.134 mm−1: bone and skin; a scattering coefficient between 1.303 and 1.461 mm−1: liver and brain; a scattering coefficient between 0.523 and 0.634 mm−1: testis and spleen. The results indicate that the scattering coefficient is tissue specific and could be used in tissue diagnosis.