Axial view of a CT scan and fused 18F FDG PET/CT image of a culture proven infected vascular prosthetic graft. In this particular case, a 67-year-old male patient underwent an urgent endovascular procedure of a contained ruptured abdominal aortic aneurysm using a Cook Zenith prosthesis. After 7 months the patient was readmitted with clinical signs of a prosthetic infection. CT scan was assessed as a possible prosthesis infection. An 18F-FDG PET/CT scan confirmed the diagnosis by showing an increased FDG uptake at the level of the endograft. Ultimately, Escherichia coli were cultured from the graft.