Side of Limb-Onset Predicts Laterality of Gray Matter Loss in Amyotrophic Lateral Sclerosis

Table 3

Global-brain volumetric measurements in total group of patients with ALS and normal controls by SIENAX.

	NC	ALS	𝑃^1	𝑃^2
BPF	0.97±0.01	0.96±0.01	0.009	0.000
NCV (mm^3)	584.0±34.6	558.7±30.2	0.001	0.000
NGMV (mm^3)	737.7±46.4	699.4±105.9	0.016	0.004
NWMV (mm^3)	697.0±38.2	675.9±30.1	0.006	0.004

BPF: brain parenchyma fraction; NCV: normalized neocortex volume; NGMV: normalized gray matter volume; NWMV: normalized white matter volume.
𝑃¹: P value in total group analysis between patients with ALS and normal controls, by using two-sample 𝑡-test.
𝑃²: P value in total group analysis between patients with ALS and normal controls, by using analysis of covariance, with age as covariate.