Side of Limb-Onset Predicts Laterality of Gray Matter Loss in Amyotrophic Lateral Sclerosis

Table 4

Global-brain volumetric measurements in ALS patients with right or left limb-onset and respective normal controls by SIENAX.

	R_NC	R_limb-onset	𝑃^1	L_NC	L_limb-onset	𝑃^2
BPF	0.97±0.007	0.96±0.009	0.000	0.974±0.006	0.971±0.005	0.016
NCV (mm^3)	576.90±34.04	551.37±28.93	0.008	588.46±35.43	566.68±25.80	0.053
NGMV (mm^3)	726.61±44.80	699.30±39.59	0.042	746.02±45.15	680.55±167.20	0.113
NWMV (mm^3)	703.38±38.84	663.01±28.44	0.001	694.24±39.67	685.97±27.15	0.402

𝑃¹,𝑃²: 𝑃 value in subgroup analysis between patients with right or left limb-onset and respective normal controls, by using analysis of covariance, adjusted for age.