Cystitis: From Urothelial Cell Biology to Clinical Applications
Figure 2
Epinephrine treatment preserves UPII expression in rat urinary bladder 24 hours after cyclophosphamide injection. UPII expression (brown) is a well-established transitional urothelial marker that is strongly expressed along the mucosal area in dilated ureter (red circle). (a) Cyclophosphamide injected rats showed a decrease or loss of UPII expression. (b) Urethral obstructed and null-treated rats at 24 hours after cyclophosphamide injection revealed a significant decrease or loss of UPII expression. (c) Intravesical epinephrine treated rats after cyclophosphamide injection showed much better expression pattern of UPII along the bladder mucosa. L: lumen of the urinary bladder or of the ureter. Scale bars (a–c) = 1000 and (a′–c′) = 200 . Reprinted from Kyung et al., 2012 [58], with permission of Springer-Verlag.
