Preparation and Characterization of Gelatin-Based Mucoadhesive Nanocomposites as Intravesical Gene Delivery Scaffolds

Figure 2

Fluorescence images of rat urothelium tissues after in vivo intravesical instillation of (a) 5% and (b) 15% hydrogels containing propidium iodide (PI, red). F344 rats were intravesical administered through a PE50 urethral catheter for 2 hours instillation. The rat bladder was harvested, embedded, and sectioned at 10 μm thickness. Samples were examined under a fluorescence microscope (Eclipse 4000, Nikon, Tokyo, Japan) (magnification ×40).

(a)

(b)