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BioMed Research International
Volume 2014, Article ID 474296, 10 pages
http://dx.doi.org/10.1155/2014/474296
Review Article

Ketogenic Diet in Neuromuscular and Neurodegenerative Diseases

1Department of Biomedical Sciences, University of Padova, Via Marzolo 3, 35031 Padova, Italy
2Sport and Exercise Sciences Research Unit, University of Palermo, Via Eleonora Duse 2, 90146 Palermo, Italy

Received 24 April 2014; Accepted 30 May 2014; Published 3 July 2014

Academic Editor: Giuseppe D’Antona

Copyright © 2014 Antonio Paoli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [74 citations]

The following is the list of published articles that have cited the current article.

  • Hyun-seung Rhyu, and Su-Youn Cho, “The effect of weight loss by ketogenic diet on the body composition, performance-related physical fitness factors and cytokines of Taekwondo athletes,” Journal of Exercise Rehabilitation, vol. 10, no. 5, pp. 326–331, 2014. View at Publisher · View at Google Scholar
  • Maya Shetreat-Klein, “Neurology and Nutrition,” Integrative Nutrition Therapy, pp. 419–438, 2015. View at Publisher · View at Google Scholar
  • Mark F. McCarty, James J. DiNicolantonio, and James H. O’Keefe, “Ketosis May Promote Brain Macroautophagy by Activating Sirt1 and Hypoxia-Inducible Factor-1,” Medical Hypotheses, 2015. View at Publisher · View at Google Scholar
  • Courtney Craig, “Mitoprotective dietary approaches for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Caloric restriction, fasting, and ketogenic diets,” Medical Hypotheses, 2015. View at Publisher · View at Google Scholar
  • Elizabeth A. Felton, and Mackenzie C. Cervenka, “Dietary therapy is the best option for refractory nonsurgical epilepsy,” Epilepsia, 2015. View at Publisher · View at Google Scholar
  • Antonio Paoli, Antonino Bianco, and Keith A. Grimaldi, “The Ketogenic Diet and Sport,” Exercise and Sport Sciences Reviews, vol. 43, no. 3, pp. 153–162, 2015. View at Publisher · View at Google Scholar
  • Kerstin Stemmer, Fabio Zani, Kirk M. Habegger, Christina Neff, Petra Kotzbeck, Michaela Bauer, Suma Yalamanchilli, Ali Azad, Maarit Lehti, Paulo J. F. Martins, Timo D. Müller, Paul T. Pfluger, and Randy J. Seeley, “FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice,” Diabetologia, 2015. View at Publisher · View at Google Scholar
  • Christopher D. Morrone, Mingzhe Liu, Sandra E. Black, and JoAnne McLaurin, “Interaction between therapeutic interventions for Alzheimer's disease and physiological A beta clearance mechanisms,” Frontiers In Aging Neuroscience, vol. 7, 2015. View at Publisher · View at Google Scholar
  • Antonio Paoli, Tatiana Moro, Gerardo Bosco, Antonino Bianco, Keith A. Grimaldi, Enrico Camporesi, and Devanand Mangar, “Effects of n-3 Polyunsaturated Fatty Acids (omega-3) Supplementation on Some Cardiovascular Risk Factors with a Ketogenic Mediterranean Diet,” Marine Drugs, vol. 13, no. 2, pp. 996–1009, 2015. View at Publisher · View at Google Scholar
  • Antonio Paoli, Gerardo Bosco, Enrico M. Camporesi, and Devanand Mangar, “Ketosis, ketogenic diet and food intake control: a complex relationship,” Frontiers in Psychology, vol. 6, 2015. View at Publisher · View at Google Scholar
  • Debbie Novick, “Nutritional Ketosis- What Does that Mean and How Can it Revolutionize Human Health and Wellness?,” International Journal of Complementary & Alternative Medicine, vol. 2, no. 2, 2015. View at Publisher · View at Google Scholar
  • Anissa Cherif, Bart Roelands, Romain Meeusen, and Karim Chamari, “Effects of Intermittent Fasting, Caloric Restriction, and Ramadan Intermittent Fasting on Cognitive Performance at Rest and During Exercise in Adults,” Sports Medicine, 2015. View at Publisher · View at Google Scholar
  • JoAnne McLaurin, Christopher Morrone, Mingzhe Liu, and Sandra Black, “Interaction between therapeutic interventions for alzheimer's disease and physiological Aβ clearance mechanisms,” Frontiers in Aging Neuroscience, vol. 7, 2015. View at Publisher · View at Google Scholar
  • Sara C. LaHue, Cynthia L. Comella, and Caroline M. Tanner, “The best medicine? The influence of physical activity and inactivity on Parkinson's disease,” Movement Disorders, 2016. View at Publisher · View at Google Scholar
  • Mark F. McCarty, and James J. DiNicolantonio, “Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity,” Open Heart, vol. 3, no. 2, 2016. View at Publisher · View at Google Scholar
  • Junfang Wu, Anna Wuolikainen, Miles Trupp, Pär Jonsson, Stefan L. Marklund, Peter M. Andersen, Lars Forsgren, and Anders Öhman, “NMR analysis of the CSF and plasma metabolome of rigorously matched amyotrophic lateral sclerosis, Parkinson’s disease and control subjects,” Metabolomics, vol. 12, no. 6, 2016. View at Publisher · View at Google Scholar
  • Ornella I. Selmin, Alberto P. G. Romagnolo, and Donato F. Romagnolo, “Mediterranean Diet and Neurodegenerative Diseases,” Mediterranean Diet, pp. 153–164, 2016. View at Publisher · View at Google Scholar
  • Erickson, and Boscheri, “Ketogenic Diets,” Aktuelle Ernahrungsmedizin, vol. 41, no. 6, pp. 458–476, 2016. View at Publisher · View at Google Scholar
  • Łukasz P Zieliński, Anthony C Smith, Alexander G Smith, and Alan J Robinson, “Metabolic flexibility of mitochondrial respiratory chain disorders predicted by computer modelling,” Mitochondrion, vol. 31, pp. 45–55, 2016. View at Publisher · View at Google Scholar
  • Klaus W. Lange, Katharina M. Lange, Ewelina Makulska-Gertruda, Yukiko Nakamura, Andreas Reissmann, Shigehiko Kanaya, and Joachim Hauser, “Ketogenic diets and Alzheimer’s disease,” Food Science and Human Wellness, 2016. View at Publisher · View at Google Scholar
  • Jayasimman Rajendran, Nikica Tomašić, Heike Kotarsky, Eva Hansson, Vidya Velagapudi, Jukka Kallijärvi, and Vineta Fellman, “Effect of High-Carbohydrate Diet on Plasma Metabolome in Mice with Mitochondrial Respiratory Chain Complex III Deficiency,” International Journal of Molecular Sciences, vol. 17, no. 11, pp. 1824, 2016. View at Publisher · View at Google Scholar
  • Elvira Valera, and Eliezer Masliah, “Therapeutic approaches in Parkinson's disease and related disorders,” Journal of Neurochemistry, pp. 346–352, 2016. View at Publisher · View at Google Scholar
  • Masabumi Funakoshi, Yasumasa Nishito, Toshiro Aigaki, Takahiko Hara, Kosuke Tanegashima, and Yukiko Sato-Miyata, “Epigenetic regulation of the glucose transporter gene Slc2a1 by β-hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice,” Genes to Cells, vol. 22, no. 1, pp. 71–83, 2016. View at Publisher · View at Google Scholar
  • Debbie Novick DC, “Obesity is now a Pandemic Worldwide: Is the Lazy, Couch Potato, Over Eating Culture at Fault?,” Advances in Obesity, Weight Management & Control, vol. 4, no. 1, 2016. View at Publisher · View at Google Scholar
  • Sviatlana V. Hrynevich, Tatyana V. Waseem, Audrey Hébert, Luc Pellerin, and Sergei V. Fedorovich, “β-hydroxybutyrate supports synaptic vesicle cycling but reduces endocytosis and exocytosis in rat brain synaptosomes,” Neurochemistry International, 2016. View at Publisher · View at Google Scholar
  • Bosco Gerardo, “Ketogenic diet and sport: Facts and fallacies,” Acta Medica Mediterranea, vol. 32, no. 5, pp. 1603–1604, 2016. View at Publisher · View at Google Scholar
  • Maya Shetreat-Klein, “19 Neurology and Nutrition,” Integrating Nutrition Into Practice, pp. 419–438, 2017. View at Publisher · View at Google Scholar
  • Nathan M. D’Cunha, Andrew J. McKune, Demosthenes B. Panagiotakos, Ekavi N. Georgousopoulou, Jackson Thomas, Duane D. Mellor, and Nenad Naumovski, “Evaluation of dietary and lifestyle changes as modifiers of S100β levels in Alzheimer’s disease,” Nutritional Neuroscience, pp. 1–18, 2017. View at Publisher · View at Google Scholar
  • Jae-Moon Kim, “Ketogenic Diet: Old Treatment, New Beginning,” Clinical Neurophysiology Practice, 2017. View at Publisher · View at Google Scholar
  • Andrea Fuso, and Cristina Domenichelli, “Diet, Epigenetics, and Alzheimer’s Disease,” Handbook of Nutrition, Diet, and Epigenetics, pp. 1–17, 2017. View at Publisher · View at Google Scholar
  • Mary Board, Colleen Lopez, Christian van den Bos, Richard Callaghan, Kieran Clarke, and Carolyn Carr, “Acetoacetate is a more efficient energy-yielding substrate for human mesenchymal stem cells than glucose and generates fewer reactive oxygen species.,” The International Journal of Biochemistry & Cell Biology, 2017. View at Publisher · View at Google Scholar
  • Fernanda Rafaela Jardim, Fernando Tonon de Rossi, Marielle Xavier Nascimento, Renata Gabriele da Silva Barros, Paula Agrizzi Borges, Isabella Cristina Prescilio, and Marcos Roberto de Oliveira, “Resveratrol and Brain Mitochondria: a Review,” Molecular Neurobiology, 2017. View at Publisher · View at Google Scholar
  • Julie M. Jones, Renee Korczak, Roberto J. Pern, and Hans J. Braun, “Carbohydrates and vitamins from grains and their relationships to mild cognitive impairment, Alzheimer's disease, and Parkinson's disease,” Cereal Foods World, vol. 62, no. 2, pp. 65–75, 2017. View at Publisher · View at Google Scholar
  • Soheila Khodadadi, Somaye Mirshekar, Reza Ghiasvand, Somayeh Shahraki Dehsoukhteh, Nafiseh Sobhani, Makan Pourmasoumi, and Maryam Miraghajani, “Tumor cells growth and survival time with the ketogenic diet in animal models: A systematic review,” International Journal of Preventive Medicine, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Tom E. J. Theunissen, Mike Gerards, Debby M. E. I. Hellebrekers, Florence H. van Tienen, Rick Kamps, Suzanne C. E. H. Sallevelt, Elvira N. M. M.-D. Hartog, Hans R. Scholte, Robert M. Verdijk, Kees Schoonderwoerd, Irenaeus F. M. de Coo, Radek Szklarczyk, and Hubert J. M. Smeets, “Selection and Characterization of Palmitic Acid Responsive Patients with an OXPHOS Complex I Defect,” Frontiers in Molecular Neuroscience, vol. 10, 2017. View at Publisher · View at Google Scholar
  • Samuel Frey, Guillaume Geffroy, Valerie Desquiret-Dumas, Naig Gueguen, Celine Bris, Sophie Belal, Patrizia Amati-Bonneau, Arnaud Chevrollier, Magalie Barth, Daniel Henrion, Guy Lenaers, Dominique Bonneau, Pascal Reynier, and Vincent Procaccio, “The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1863, no. 1, pp. 284–291, 2017. View at Publisher · View at Google Scholar
  • H. White, P. Kruger, and B. Venkatesh, “Novel Metabolic Substrates for Feeding the Injured Brain,” Annual Update in Intensive Care and Emergency Medicine 2017, pp. 329–341, 2017. View at Publisher · View at Google Scholar
  • Li-Peng Yang, and Dong-Sheng Fan, “Diets for patients with amyotrophic lateral sclerosis: Pay attention to nutritional intervention,” Chinese Medical Journal, vol. 130, no. 15, pp. 1765–1767, 2017. View at Publisher · View at Google Scholar
  • Young-min Han, Tatiana Bedarida, Ye Ding, Brian K. Somba, Qiulun Lu, Qilong Wang, Ping Song, and Ming-Hui Zou, “β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4,” Molecular Cell, 2018. View at Publisher · View at Google Scholar
  • Mustafa Fevzi KaragÖZ, and Nilüfer Acar Tek, “Diyet Yağlarının Alzheimer Hastalığı Patolojisi Üzerine Potansiyel Koruyucu Etkileri,” SDÜ Sağlık Bilimleri Dergisi, 2018. View at Publisher · View at Google Scholar
  • Qi Liu, Xiaomeng Wang, Zucheng Huang, Junhao Liu, Jianyang Ding, Xiaolin Xu, Ganggang Kong, Xiuhua Wu, Zhou Yang, and Qingan Zhu, “Ketogenic diet delays spinal fusion and decreases bone mass in posterolateral lumbar spinal fusion: an in vivo rat model,” Acta Neurochirurgica, 2018. View at Publisher · View at Google Scholar
  • Hu Erling, Du Huan, Zhu Xinliang, Wang Leilei, Shang Sen, Wu Xingjuan, Lu Haixia, and Lu Xiaoyun, “Beta-hydroxybutyrate promotes the expression of BDNF in hippocampal neurons under adequate glucose supply,” Neuroscience, 2018. View at Publisher · View at Google Scholar
  • Fred Fung, Huei-Shyong Wang, and Suresh Menon, “Food safety in the 21st century,” Biomedical Journal, 2018. View at Publisher · View at Google Scholar
  • Iwona Żarnowska, Beata Chrapko, Grażyna Gwizda, Anna Nocuń, Krystyna Mitosek-Szewczyk, and Maciej Gasior, “Therapeutic use of carbohydrate-restricted diets in an autistic child; a case report of clinical and 18FDG PET findings,” Metabolic Brain Disease, 2018. View at Publisher · View at Google Scholar
  • Alessandro Pinto, Alessio Bonucci, Elisa Maggi, Mariangela Corsi, and Rita Businaro, “Anti-Oxidant and Anti-Inflammatory Activity of Ketogenic Diet: New Perspectives for Neuroprotection in Alzheimer’s Disease,” Antioxidants, vol. 7, no. 5, pp. 63, 2018. View at Publisher · View at Google Scholar
  • Antonio Paoli, Lorenzo Cenci, Hesham R. Omar, Prachiti Dalvi, Silvia QUartesan, Alberto Fiorito, Gerardo Bosco, Enrico M. Camporesi, and Devanand Mangar, “Internist, anesthesiologist and surgeon use of ketogenic diet,” Minerva Gastroenterologica e Dietologica, vol. 64, no. 1, pp. 84–93, 2018. View at Publisher · View at Google Scholar
  • Aysel Sarl, Sait Ozturk, Fatih Serhat Erol, Ramazan Ulu, Bekir Akgun, and Ibrahim Hanifi Ozercan, “Effects of mucuna pruriens on free fatty acid levels and histopathological changes in the brains of rats fed a high fructose diet,” Medical Principles and Practice, vol. 26, no. 6, pp. 561–566, 2018. View at Publisher · View at Google Scholar
  • Abbi R. Hernandez, Caesar M. Hernandez, Keila Campos, Leah Truckenbrod, Quinten Federico, Brianna Moon, Joseph A. McQuail, Andrew P. Maurer, Jennifer L. Bizon, and Sara N. Burke, “A Ketogenic Diet Improves Cognition and Has Biochemical Effects in Prefrontal Cortex That Are Dissociable From Hippocampus,” Frontiers in Aging Neuroscience, vol. 10, 2018. View at Publisher · View at Google Scholar
  • Nina Mohorko, Maša Černelič-Bizjak, Tamara Poklar-Vatovec, Gašper Grom, Saša Kenig, Ana Petelin, and Zala Jenko-Pražnikar, “Weight loss, improved physical performance, cognitive function, eating behavior and metabolic profile in a 12-week ketogenic diet in obese adults,” Nutrition Research, 2018. View at Publisher · View at Google Scholar
  • Komal Panchal, and Anand Krishna Tiwari, “Mitochondrial dynamics, a key executioner in neurodegenerative diseases,” Mitochondrion, 2018. View at Publisher · View at Google Scholar
  • Miho Ota, Junko Matsuo, Ikki Ishida, Harumasa Takano, Yuma Yokoi, Hiroaki Hori, Sumiko Yoshida, Kinya Ashida, Kentaro Nakamura, Takeshi Takahashi, and Hiroshi Kunugi, “Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer's disease,” Neuroscience Letters, 2018. View at Publisher · View at Google Scholar
  • Jenny B. Koenig, and Chris G. Dulla, “Dysregulated Glucose Metabolism as a Therapeutic Target to Reduce Post-traumatic Epilepsy,” Frontiers in Cellular Neuroscience, vol. 12, 2018. View at Publisher · View at Google Scholar
  • Charlotte Veyrat-Durebex, Pascal Reynier, Vincent Procaccio, Rudolf Hergesheimer, Philippe Corcia, Christian R. Andres, and Hélène Blasco, “How Can a Ketogenic Diet Improve Motor Function?,” Frontiers in Molecular Neuroscience, vol. 11, 2018. View at Publisher · View at Google Scholar
  • Karen K. Ryan, Matthias H. Tschöp, Randy J. Seeley, Jayna Stout, Kristen Ludwick, Amy E. B. Packard, Kirk M. Habegger, Sarah M. Fourman, Abigail M. K. Thompson, Nobuyuki Itoh, Diego Perez-Tilve, Yvonne M. Ulrich-Lai, Karlton R. Larson, and Kerstin Stemmer, “Dietary manipulations that induce ketosis activate the HPA axis in male rats and mice: A potential role for fibroblast growth factor-21,” Endocrinology, vol. 159, no. 1, pp. 400–413, 2018. View at Publisher · View at Google Scholar
  • Vincent J. Miller, Frederick A. Villamena, and Jeff S. Volek, “Nutritional Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health,” Journal of Nutrition and Metabolism, vol. 2018, pp. 1–27, 2018. View at Publisher · View at Google Scholar
  • Senkuttuvan Rajendiran, Gunniya Hariyanandam Gunasekar, and Sungho Yoon, “A heterogenized cobaltate catalyst on a bis-imidazolium-based covalent triazine framework for hydroesterification of epoxides,” New Journal of Chemistry, 2018. View at Publisher · View at Google Scholar
  • Elisa Felix-Soriano, María J. Moreno-Aliaga, María J. Ramirez, and Maite Solas, “Interactions Between Age, Diet, and Insulin and Their Effect on Cognition,” Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases, pp. 223–238, 2018. View at Publisher · View at Google Scholar
  • Shuo Wang, George M Smith, Michael E. Selzer, and Shuxin Li, “Emerging molecular therapeutic targets for spinal cord injury,” Expert Opinion on Therapeutic Targets, vol. 23, no. 9, pp. 787–803, 2019. View at Publisher · View at Google Scholar
  • Marta Rusek, Ryszard Pluta, Marzena Ułamek-Kozioł, and Stanisław J. Czuczwar, “Ketogenic Diet in Alzheimer’s Disease,” International Journal of Molecular Sciences, vol. 20, no. 16, pp. 3892, 2019. View at Publisher · View at Google Scholar
  • Fionn T. McSwiney, and Lorna Doyle, “Low-Carbohydrate Ketogenic Diets in Male Endurance Athletes Demonstrate Different Micronutrient Contents and Changes in Corpuscular Haemoglobin over 12 Weeks,” Sports, vol. 7, no. 9, pp. 201, 2019. View at Publisher · View at Google Scholar
  • Gerardo Bosco, Antonio Paoli, Alex Rizzato, Giuseppe Marcolin, Maria Teresa Guagnano, Christian Doria, Suwas Bhandari, Tiziana Pietrangelo, and Vittore Verratti, “Body Composition and Endocrine Adaptations to High-Altitude Trekking in the Himalayas,” 2019. View at Publisher · View at Google Scholar
  • Seema Patel, “Nutrition, Immunity, and Neurological Diseases,” Nutrition and Immunity, pp. 395–406, 2019. View at Publisher · View at Google Scholar
  • Jenny B. Koenig, David Cantu, Cho Low, Mary Sommer, Farzad Noubary, Danielle Croker, Michael Whalen, Dong Kong, and Chris G. Dulla, “Glycolytic inhibitor 2-deoxyglucose prevents cortical hyperexcitability after traumatic brain injury,” JCI Insight, vol. 4, no. 11, 2019. View at Publisher · View at Google Scholar
  • Alessandro Leone, Ramona De Amicis, Chiara Lessa, Anna Tagliabue, Claudia Trentani, Cinzia Ferraris, Alberto Battezzati, Pierangelo Veggiotti, Andrea Foppiani, Simone Ravella, and Simona Bertoli, “Food and Food Products on the Italian Market for Ketogenic Dietary Treatment of Neurological Diseases,” Nutrients, vol. 11, no. 5, pp. 1104, 2019. View at Publisher · View at Google Scholar
  • W.M.A.D. Binosha Fernando, Veer B. Gupta, Vijay Jayasena, Charles S. Brennan, and Ralph N. Martins, “Carbohydrate and Protein Metabolism: Influences on Cognition and Alzheimer's Disease,” Neurodegeneration and Alzheimer's Disease, pp. 149–187, 2019. View at Publisher · View at Google Scholar
  • Devin Wahl, Samantha M. Solon-Biet, Victoria C. Cogger, Luigi Fontana, Stephen J. Simpson, David G. Le Couteur, and Rosilene V. Ribeiro, “Aging, lifestyle and dementia,” Neurobiology of Disease, pp. 104481, 2019. View at Publisher · View at Google Scholar
  • Elena C. Gross, Rainer J. Klement, Jean Schoenen, Dominic P. D’Agostino, and Dirk Fischer, “Potential Protective Mechanisms of Ketone Bodies in Migraine Prevention,” Nutrients, vol. 11, no. 4, pp. 811, 2019. View at Publisher · View at Google Scholar
  • Angelia M. Holland, Ahmed S. Qazi, Kristen N. Beasley, and Hannah R. Bennett, “Blood and cardiovascular health parameters after supplementing with ketone salts for six weeks,” Journal of Insulin Resistance, vol. 4, no. 1, 2019. View at Publisher · View at Google Scholar
  • Chang Moo Kang, BoKyeong Yun, Minju Kim, Mina Song, Yeon-hee Kim, Sung Hwan Lee, Hosun Lee, Song Mi Lee, and Seung-Min Lee, “Postoperative serum metabolites of patients on a low carbohydrate ketogenic diet after pancreatectomy for pancreatobiliary cancer: a nontargeted metabolomics pilot study,” Scientific Reports, vol. 9, no. 1, 2019. View at Publisher · View at Google Scholar
  • Yurika Katsu-Jiménez, and Alfredo Giménez-Cassina, “Fibroblast growth Factor-21 promotes ketone body utilization in neurons through activation of AMP-dependent kinase,” Molecular and Cellular Neuroscience, pp. 103415, 2019. View at Publisher · View at Google Scholar
  • Marie Lindefeldt, Alexander Eng, Hamid Darban, Annelie Bjerkner, Cecilia K Zetterström, Tobias Allander, Björn Andersson, Elhanan Borenstein, Maria Dahlin, and Stefanie Prast-Nielsen, “The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy,” npj Biofilms and Microbiomes, vol. 5, no. 1, 2019. View at Publisher · View at Google Scholar
  • Andrea Fuso, and Cristina Domenichelli, “Diet, Epigenetics, and Alzheimer’s Disease,” Handbook of Nutrition, Diet, and Epigenetics, pp. 987–1003, 2019. View at Publisher · View at Google Scholar
  • Dariusz Włodarek, “Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer’s Disease and Parkinson’s Disease),” Nutrients, vol. 11, no. 1, pp. 169, 2019. View at Publisher · View at Google Scholar
  • Elena Gross, Niveditha Putananickal, Anna-Lena Orsini, Simone Schmidt, Deborah R. Vogt, Sven Cichon, Peter Sandor, and Dirk Fischer, “Efficacy and safety of exogenous ketone bodies for preventive treatment of migraine: A study protocol for a single-centred, randomised, placebo-controlled, double-blind crossover trial,” Trials, vol. 20, no. 1, 2019. View at Publisher · View at Google Scholar