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BioMed Research International
Volume 2014 (2014), Article ID 475379, 8 pages
Research Article

Identification of Modules Related to Programmed Cell Death in CHD Based on EHEN

1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150000, China
2Institute of Opto-Electronics, Harbin Institute of Technology, Harbin, Heilongjiang 150000, China
3Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, China

Received 27 March 2014; Accepted 28 May 2014; Published 15 July 2014

Academic Editor: Dong Wang

Copyright © 2014 Xu Jia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The formation and death of macrophages and foam cells are one of the major factors that cause coronary heart disease (CHD). In our study, based on the Edinburgh Human Metabolic Network (EHMN) metabolic network, we built an enzyme network which was constructed by enzymes (nodes) and reactions (edges) called the Edinburgh Human Enzyme Network (EHEN). By integrating the subcellular location information for the reactions and refining the protein-reaction relationships based on the location information, we proposed a computational approach to select modules related to programmed cell death. The identified module was in the EHEN-mitochondria (EHEN-M) and was confirmed to be related to programmed cell death, CHD pathogenesis, and lipid metabolism in the literature. We expected this method could analyze CHD better and more comprehensively from the point of programmed cell death in subnetworks.