Preliminary In Vitro and In Vivo Evaluation of Antidiabetic Activity of Ducrosia anethifolia Boiss. and Its Linear Furanocoumarins

Table 4

Effect of Ducrosia anethifolia total extract on NO, MDA levels, antioxidant, and antioxidant enzyme in STZ-induced diabetes in rats.

Groups	Parameters
	Normal control	D. anethifolia treated normal	STZ treated	STZ + D. anethifolia treated	STZ + glibenclamide
NO	43.68±0.7^a	43.50±4.13^a	78.19±1.00^b	51.05±3.21^c	51.00±9.91^c
MDA	18.53±1.19^a	17.56±0.29^a	124.11±8.47^b	25.36±4.53^c	23.10±4.63^c
GSH	3.40±0.30^a	3.61±0.34^a	1.01±0.05^b	2.45±0.23^c	2.67±0.38^c
SOD	9.88±0.67^a	8.78±0.18^a	1.67±0.17^b	6.00±1.10^c	7.00±1.30^c

Data are means ± SD of ten rats in each group. Blood glucose level is expressed in mg/dL. MDA is expressed in 𝜇moL/min/g tissue. GSH is expressed as 𝜇g glutathione/mg protein and SOD is expressed in 𝜇mol/mg protein/min. NO is expressed in 𝜇g/g tissue. Statistical analysis is carried out using one-way analysis of variance (ANOVA) using CoStat Computer Program. The different groups were compared with each other at the same time and the unshared letter is significantly different at 𝑃≤0.05.