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BioMed Research International
Volume 2014 (2014), Article ID 480573, 11 pages
Review Article

A Clinical and Pathological Overview of Vulvar Condyloma Acuminatum, Intraepithelial Neoplasia, and Squamous Cell Carcinoma

1Department of Pathology, University Hospital of Liège, 4000 Liège, Belgium
2Department of Gynecology, University Hospital of Liège, 4000 Liège, Belgium
3Laboratory of Experimental Pathology, GIGA-Cancer, University of Liège, 4000 Liège, Belgium

Received 15 November 2013; Accepted 15 January 2014; Published 25 February 2014

Academic Editor: Gérald E. Piérard

Copyright © 2014 Boris Léonard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma are three relatively frequent vulvar lesions. Condyloma acuminatum is induced by low risk genotypes of human papillomavirus (HPV). Vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma have different etiopathogenic pathways and are related or not with high risk HPV types. The goal of this paper is to review the main pathological and clinical features of these lesions. A special attention has been paid also to epidemiological data, pathological classification, and clinical implications of these diseases.