Antisecretory Effect of Hydrogen Sulfide on Gastric Acid Secretion and the Involvement of Nitric Oxide

Figure 1

NaHS decreased the gastric acid output induced by distention (1.5 mL/100 g of body weight by normal saline and pH 7 and 37°C for 90 min). C: control, NaHS: animals received NaHS (80 μg/kg, i.v.) just prior to stimulation of the gastric acid secretion, NaHS + L-NAME: animals received L-NAME at 10 mg/kg, i.v., 5 min before the administration of NaHS (80 μg/kg, i.v.), PAG: rats received cystathionine-γ-lyase inhibitor, propargylglycine (PAG), at 50 mg/kg, i.v. concomitant with the gastric distention, PAG + SNP: animals received PAG at 50 mg/kg, i.v. + SNP (a NO donor at 6 mg/kg intragastrically) concomitant with the gastric distention. Asterisk indicates a significant decrease (^∗𝑃<0.01) as compared to the control group; 𝜒 in the above column indicates a significant increase (^𝝌𝑃<0.01) as compared to NaHS-treated group; ^𝜶𝑃<0.05 as compared with PAG + SNP group; 𝛽 in the above column indicates a significant increase (^𝛽𝑃<0.01) as compared to the control. Data are expressed as mean ± S.E.M.