Pepsinogen II Can Be a Potential Surrogate Marker of Morphological Changes in Corpus before and after H. pylori Eradication
Table 3
Concentrations of pepsinogen I, pepsinogen II, and pepsinogen I to II ratio by histological categories1 in antrum and corpus in first-degree relatives of patients with gastric adenocarcinoma after successful H. pylori eradication ().
Pepsinogen I (g/mL)
Pepsinogen II (g/mL)
Pepsinogen ratio
Median
IQR2
Median
IQR
Median
IQR
Antrum
Neutrophil cell infiltration
High
32.5
—
13.5
—
2.4
—
Low
77.3
59.0–103.5
7.1
5.3–9.5
11.3
7.9–14.9
Mononuclear cell infiltration
High
66.5
52.3–106.8
6.8
5.2–9.9
12.2
6.1–15.3
Low
80.0
59.4–103.5
7.2
5.3–9.7
10.7
8.0–14.9
Atrophy
High
82.8
63.1–119.5
6.5
5.0–8.4
13.2
10.8–16.5
Low
77.1
57.6–103.0
7.2
5.4–9.7
10.7
7.9–14.5
Intestinal metaplasia
High
66.4
58.5–91.3
5.4
4.9–10.3
13.1
10.6–14.4
Low
77.5
58.2–104.0
7.3
5.5–9.7
10.7
7.8–15.7
Corpus
Neutrophil cell infiltration
High
—
—
—
—
—
—
Low
77.1
58.7–103.1
7.1
5.3–9.6
11.2
7.9–14.8
Mononuclear cell infiltration
High
54.0*
35.6–94.8
9.4
5.8–11.6
7.9**
3.8–12.6
Low
80
60.5–104.4
6.9
5.1–9.0
11.6
8.4–15.6
Atrophy
High
68.3
40.6–125.1
10.1*
7.5–11.6
8.1
4.5–16.5
Low
80.0
59.4
6.9
5.1–9.0
11.3
8.2–14.6
Intestinal metaplasia
High
38.1**
25.8–93.5
7.8
4.7–12.8
4.1*
2.5–15.0
Low
78.4
59.6–103.1
7.1
5.3–9.4
11.3
8.2–14.7
Low score: normal or mild changes; high score: moderate or marked changes.
2IQR: interquartile range expressed as percentile 25–75.
*
& ** when pepsinogen concentrations (or pepsinogen ratio) were compared in groups of high and low histology scores (Mann-Whitney test).
