MicroRNA-24 Modulates Aflatoxin B1-Related Hepatocellular Carcinoma Prognosis and Tumorigenesis
Figure 1
Association between survival and AFB1 exposure in 207 HCC cases receiving curative treatment. According to the average level of AFB1-DNA adducts in cancerous tissues, AFB1 exposure was divided into two groups: low exposure group (relative level ≤ 2.87 μmol/mol DNA) and high exposure group (relative level > 2.87 μmol/mol DNA). AFB1 exposure levels were associated with tumor reoccurrence-free survival (a) and overall survival (b) of HCC. Cumulative hazard function was plotted by Kaplan-Meier’s methodology, and value was calculated with two-sided log-rank tests. Relative hazard ratio (HR) and corresponding 95% CI of high AFB1 exposure (compared with low exposure) was calculated using multivariable cox regression model (including all significant variables).
