MicroRNA-24 Modulates Aflatoxin B1-Related Hepatocellular Carcinoma Prognosis and Tumorigenesis

Figure 5

The joint effects of AFB1 exposure and miR-24 expression on HCC prognosis. (a and c) The joint effects of AFB1 exposure and miR-24 expression on tumor recurrence-free survival (RFS) and overall survival (OS) of HCC patients. Cumulative hazard function was plotted by Kaplan-Meier’s methodology, and 𝑃 value was calculated with two-sided log-rank tests. (b and d) Relative hazard ratio (HR) of both AFB1 exposure and miR-24 expression on HCC. HR was calculated using multivariable cox regression model (including all significant variables). Abbreviations: LALM, the combination of low AFB1 exposure level and low miR-24 expression; LAHM, the combination of low AFB1 exposure level and high miR-24 expression; HALM, the combination of high AFB1 exposure level and low miR-24 expression; HAHM, the combination of high AFB1 exposure level and high miR-24 expression.