The Interplay of Reovirus with Autophagy

Table 1

The target of viral proteins on modulators of autophagy.

Virus	Viral protein	Direct target	Downstream^#	References
Hepatitis C virus	Nonstructural protein 4B (NS4B)	Rab5 (early endosome, complex to PI3K)	None	[37]
Hepatitis C virus	NS4B	Vps34 (PI3K complex)	PIP3/Akt	[37]
Rotavirus	NSP4	Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)	AMPK	[38]
Rotavirus	NSP4	5′ adenosine monophosphate-activated protein kinase (AMPK)	TSC1/2	[39]
Herpes simplex virus type 1 (HSV-1)	ICP34.5	Beclin-1	LC3-II	[40]
Simian virus 40	Small T antigen	AMPK	mTOR	[41]
ARV	p17	p53	PTEN	[9]
ARV	p17	AMPK	mTORC1	[9]
ARV	p17	PKR/eIF2𝛼	Beclin-1	[9]
Hepatitis B virus	HBV X protein (HBx)	Phosphatidylinositol 3-kinase class III (PI3KC3)	mTOR	[42]
KSHV, HVS, and MCV*	viral FLIP	Atg3	LC3	[43–45]
CHIKV and SINV	NSP4	eIF2𝛼	ATF-4	[46]

Note: ∗Kaposi's sarcoma-associated herpesvirus (KSHV), herpesvirus saimiri (HVS), molluscum contagiosum virus (MCV).
^#Downstream effect on autophagy resulted from the interaction of viral proteins with their direct targets.