BioMed Research International / 2014 / Article / Tab 1 / Review Article
The Interplay of Reovirus with Autophagy Table 1 The target of viral proteins on modulators of autophagy.
Virus Viral protein
Direct target Downstream# References Hepatitis C virus Nonstructural protein 4B (NS4B) Rab5 (early endosome, complex to PI3K) None [37 ] Hepatitis C virus NS4B Vps34 (PI3K complex) PIP3/Akt [37 ] Rotavirus NSP4 Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) AMPK [38 ] Rotavirus NSP4 5ā² adenosine monophosphate-activated protein kinase (AMPK) TSC1/2 [39 ] Herpes simplex virus type 1 (HSV-1) ICP34.5 Beclin-1 LC3-II [40 ] Simian virus 40 Small T antigen AMPK mTOR [41 ] ARV p17 p53 PTEN [9 ] ARV p17 AMPK mTORC1 [9 ] ARV p17 PKR/eIF2
Beclin-1 [9 ] Hepatitis B virus HBV X protein (HBx) Phosphatidylinositol 3-kinase class III (PI3KC3) mTOR [42 ] KSHV, HVS, and MCV* viral FLIP Atg3 LC3 [43 ā45 ] CHIKV and SINV NSP4 eIF2
ATF-4 [46 ]
Note:
Kaposi's sarcoma-associated herpesvirus (KSHV), herpesvirus saimiri (HVS), molluscum contagiosum virus (MCV).
# Downstream effect on autophagy resulted from the interaction of viral proteins with their direct targets.