A 3’UTR Polymorphism of IL-6R Is Associated with Chinese Pediatric Tuberculosis

Table 2

The genotyping results of SNPs in IL-6 and IL-6R.

Gene	Position	Rs No.	Allele/genotype	TB (𝑛, %)	Control (𝑛, %)	OR	𝑃	Bonf 𝑃
IL6	5 near	rs17147230	A	334, 47.3	388, 48.7	0.94 [0.77–1.56]	0.58	5.79
			T	372, 52.7	408, 51.3
			AA	83, 23.5	94, 23.6		0.67	6.70
			TA	168, 47.6	200, 50.2
			TT	102, 28.9	104, 26.1
	Promoter	rs1800796	G	243, 33.7	269, 34.4	1.03 [0.83–1.28]	0.77	7.72
			C	463, 66.3	529, 65.6
			GG	43, 12.2	49, 12.3		0.90	9.00
			GC	157, 44.5	171, 42.9
			CC	153, 43.3	179, 44.9
IL-6R	Promoter	rs3887104	A	65, 9.4	56, 7.2	1.33 [0.92–1.93]	0.13	1.34
			G	629, 90.6	720, 92.8
			AA	3, 0.9	0, 0		0.06	0.63
			AG	59, 17.0	56, 4.4
			GG	285, 82.1	332, 85.6
	5 UTR	rs4845617	A	370, 47.4	322, 48.6	0.95 [0.77–1.17]	0.65	6.48
			G	358, 52.6	392, 51.4
			AA	78, 22.9	90, 23.6		0.87	8.70
			AG	166, 48.8	190, 49.9
			GG	96, 28.2	101, 26.5
	Intron	rs7411976	C	39, 5.6	34, 4.4	1.27 [0.79–2.04]	0.32	3.19
			A	661, 94.4	732, 95.6
			CC	2, 0.6	0, 0		0.20	2.00
			CA	35, 10	34, 8.9
			AA	313, 89.4	349, 91.1
	Intron	rs4845618	G	320, 46.1	342, 44.0	1.09 [0.89–1.34]	0.41	4.08
			T	374, 53.9	436, 56.0
			GG	77, 22.2	73, 18.8		0.51	5.10
			GT	166, 47.8	196, 50.4
			TT	104, 30	120, 30.9
	Intron	rs4845626	T	57, 8.1	71, 8.9	0.90 [0.63–1.30]	0.58	5.78
			G	649, 92.9	729, 91.1
			TT	4, 1.1	1, 0.2		0.15	1.50
			TG	49, 13.9	69, 17.2
			GG	300, 85.0	330, 82.5
	Missense	rs2228145	C	290, 41.7	350, 46.5	0.82 [0.67–1.01]	0.06	0.62
			A	406, 58.3	402, 53.5
			CC	60, 17.2	81, 21.5		0.17	1.70
			CA	170, 48.9	188, 50.0
			AA	118, 33.9	107, 28.5
	3 UTR	rs2229238	T	46, 6.5	87, 10.9	0.57 [0.39–0.83]	0.003	0.03
			C	660, 93.5	711, 89.1
			TT	2, 0.6	2, 0.5		0.004	0.04
			TC	42, 11.9	83, 20.8
			CC	309, 87.5	314, 78.7
	3 UTR	rs3828078	A	43, 6.1	34, 4.3	1.46 [0.92–2.31]	0.11	1.08
			G	663, 93.9	764, 95.7
			AA	0, 0	2, 0.5		0.03	0.29
			AG	43, 12.2	30, 7.5
			GG	310, 87.8	367, 92.0

Logistic regression analyses were used for calculating OR (95% CI: confidence interval). Value was determined by Fisher's exact test.