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BioMed Research International
Volume 2014 (2014), Article ID 485723, 6 pages
http://dx.doi.org/10.1155/2014/485723
Research Article

Iron Metabolism Disturbance in a French Cohort of ALS Patients

1Unité Mixte de Recherche U930, Institut National de la Santé et de la Recherche Médicale, Université François-Rabelais, Equipe “Neurogénétique et Neurométabolomique”, 10 boulevard Tonnellé, 37032 Tours, France
2Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France
3Centre SLA, Service de Neurologie, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France
4Service de Neurologie, Centre Hospitalier Régional Universitaire de Lille, 59037 Lille, France
5Laboratoire de Biochimie, Hôpital Trousseau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France
6Service de Médecine Interne, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France

Received 14 April 2014; Revised 16 June 2014; Accepted 18 June 2014; Published 2 July 2014

Academic Editor: Aaron S. Dumont

Copyright © 2014 Charlotte Veyrat-Durebex et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The aim of this study was to assess iron status in a cohort of amyotrophic lateral sclerosis (ALS) patients compared to controls in order to evaluate these parameters as a risk factor or a modifying factor of ALS. Methods. We collected serum iron, ferritin, transferrin, total iron-binding capacity, and transferrin saturation coefficient (TSC) from 104 ALS patients at the time of diagnosis and from 145 controls. We reported phenotypic characteristics and evolution parameters such as ALSFRS-R and forced vital capacity at diagnosis and after one year of follow-up. In a first step we compared iron status between ALS patients and controls, and then we evaluated the relation between iron status and disease evolution of ALS patients using univariate and multivariate analysis. Results. We observed increased concentrations of serum iron ( ) and ferritin ( ) and increased TSC ( ) in ALS patients. We also showed an association between markers of iron status and high body weight loss in ALS patients. The multivariate analysis of survival highlighted a significant relation between ferritin level and disease duration ( ). Conclusion. This is the first study showing a higher concentration of serum iron in ALS patients, strengthening the involvement of a deregulation of iron metabolism in ALS.