The Impact of Extracellular Vesicle-Encapsulated Circulating MicroRNAs in Lung Cancer Research

Figure 2

Circulating microRNAs as a promising biomarker platform in lung cancer. Circulating miRNAs have been found to be packaged into various membrane-bound vesicles, such as exosomes and microvesicles and to exist in a vesicle-free form associated with protein or high-density lipoprotein complexes. Extracellular vesicles (EVs), such as exosomes and microvesicles, are recognized as novel tools for cell-cell communication and might be predictive biomarkers for cancer malignancy. EVs that circulate in body fluids can be readily recovered using several existing isolation methods and analyzed by various detection methods.