The Role of M1 and M2 Macrophages in Prostate Cancer in relation to Extracapsular Tumor Extension and Biochemical Recurrence after Radical Prostatectomy

Table 1

Clinical presentation, pathologic findings, and follow-up of the 93 patients.

Macrophages population	Total of patients	M1	M2
𝑛 (%)	93	34 (36.6)	59 (63.4)
Count in three hot spots	Mean (median)	12.06 (6)	17.18 (10)
Density of macrophages M1 and M2 in three hot spots according to median number	43 below median number; 50 above median number
Preoperative variables
Age (yy) median (IQR)	67 (45–75)	64 (55–74)	67 (45–75)
Total PSA (ng/mL) median (IQR)	7.6 (1.0–86.8)	8.3 (2.5–47.7)	7.0 (1–76.8)
Biopsy Gleason score 𝑛 (%)
6	50 (53.8)	19 (55.9)	31 (52.6)
7	28 (30.1)	12 (35.3)	16 (27.1)
8–10	15 (16.1)	3 (8.8)	12 (20.3)
Postoperative variables
Organ confine disease (OC) 𝑛 (%)	33 (35.5)	19 (55.9)	14 (23.8)
Extracapsular extension (ECE) 𝑛 (%)	60 (64.5)	15 (44.1)	45 (76.2)
TNM stage 𝑛 (%)
T2	33 (35.5)	19 (55.9)	14 (23.8)
T3a	35 (37.6)	7 (20.6)	28 (47.4)
T3b	23 (24.8)	8 (23.5)	15 (25.4)
T4	2 (2.1)	0	2 (3.4)
Pathologic Gleason score 𝑛 (%)
6	30 (32.2)	13 (38.2)	17 (28.8)
7	40 (43)	16 (47.1)	24 (40.7)
8–10	23 (24.8)	5 (14.7)	18 (30.5)
Lymph node involvement 𝑛 (%)	5 (5.3)	2 (5.9)	3 (5.1)
Positive surgical margin 𝑛 (%)	11 (11.8)	2 (5.9)	9 (15.2)
Follow-up (months) mean (SD)	50.4 (19.2)	55.5 (21.2)	47.6 (16.3)
Biochemical recurrence 𝑛 (%)	23 (24.7)	7 (20.6)	16 (27.1)