Prognostic Significance of Sentinel Lymph Node Mapping in Merkel Cell Carcinoma: Systematic Review and Meta-Analysis of Prognostic Studies

Table 2

Detailed survival analysis of the cases included in the individual patient analysis (𝑛=172).

Factor	Number of patients	HR for OS [95% CI]	𝑃 value	HR for DFS [95% CI]	𝑃 value
Age	Mean 68.58	1.039 [0.98–1.09]	0.13	1.003 [0.97–1.03]	0.83
Tumor size	Mean 1.85	0.59 [0.23–1.5]	0.27	1.017 [0.65–1.53]	0.93
Gender			0.212		0.55
Male	78	1.86 [0.69–5.02]		1.23 [0.62–2.44]
Female	83	Referent		Referent
Regional nodal treatment
None	100	0.17 [0.04–0.72]	0.16	0.28 [0.1–0.78]	0.015
Nodal dissection	23	0.78 [0.18–3.31]	0.74	0.68 [0.22–2.14]	0.51
Radiotherapy	37	0.66 [0.11–3.99]	0.65	0.37 [0.1–1.29]	0.12
Both	12	Referent	Referent	Referent	Referent
Tumor location
Limbs	95	0.95 [0.33–2.71]	0.93	0.73 [0.37–1.46]	0.38
Trunk	8	2.08 [0.24–17.52]	0.46	1.95 [0.56–6.77]	0.29
Head and neck	69	Referent	Referent	Referent	Referent
SLN status			0.002		0.015
Positive	65	6.13 [1.97–19.07]		2.25 [1.16–4.33]
Negative	107	Referent		Referent