Modulation of TLR 3, 7 and 8 Expressions in HCV Genotype 3 Infected Individuals: Potential Correlations of Pathogenesis and Spontaneous Clearance
Table 1
Baseline characteristics of patients enrolled in this study.
Control
HCV infected (treatment naïve)
Recombinant IFN treated
Spontaneous clearance
Relapsed
Cirrhosis of liver
Number of patients
n = 20
n = 20
n = 20
n = 20
n = 20
n = 20
Mean age (range), years
46 (30–62)
48 (31–64)
31 (31–54)
28 (20–48)
47 (30–60)
52 (33–68)
Gender (male : female)
10 : 10
15 : 05
14 : 06
14 : 06
18 : 02
15 : 05
Median BMI (range), kg/m2
26 (21–32)
24 (30–38)
26 (21–32)
30 (21–39)
25.5 (20–38)
26 (31–35)
ALT! ± SD (IU/L)
37.42 ± 6.8
156 ± 6.3
121 ± 3.6
85 ± 5.8
126 ± 2.3
140 ± 8.5
AST# ± SD (IU/L)
34.65 ± 14.22
118 ± 5.5
156 ± 3.0
114 ± .3
125.23 ± 2.6
156 ± 4.3
Median HCV RNA levels at baseline ( IU/ml)
—
425 (10–6500)
25 (25–650)
BDL
1560 (107–20000)
3265 (129–2000)
Alanine aminotransferase level shown in IU/L with its standard deviations.
#Alanine aspartate aminotransferase level shown in IU/L with its standard deviations. All enzymatic methods were done at 37°C, in a Beckman Coulter Synchron CX5 PRO, USA, instrument. SD: standard deviation, BMI: basal metabolic index, and BDL: below detection limit.
