Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin

Table 2

Different heat shock proteins, their localization, functions, and involvement in different neurodegenerative diseases.

HSPs	MW (kDa)	Localization	Colocalization	Functions	Involved in diseases
HSP10	10	Mitochondria, cytosol, ER, and nucleus	A	Protein folding	AD, MS, and tauopathies
HSP27	20–30	Cytosol, ER, and nucleus	Tau, A, HTT, and -synuclein	Protein degradation	AD, HD, and PD
HSP40	40	Cytosol	HTT and -synuclein	Protein folding	HD and PD
HSP60	60	Mitochondria	A	Prevent protein aggregation	AD
HSP70	70	Cytosol, ER, nucleus, and mitochondria	A, HTT, -synuclein, and PrP^c	Protein folding/unfolding	AD, HD, PD, Prion, and MS
HSP90	90	Cytosol and ER	A, HTT, -synuclein, and PrP^c	Protein degradation and transcription factor	AD, PD, and HD
HSP104/110	100–110	Cytosol and ER	-synuclein and PrP^c	Thermal tolerance	PD and prion