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BioMed Research International
Volume 2014, Article ID 501213, 12 pages
http://dx.doi.org/10.1155/2014/501213
Review Article

A Comprehensive Review of Contemporary Role of Local Treatment of the Primary Tumor and/or the Metastases in Metastatic Prostate Cancer

1Department of Urology, Jules Bordet Institute, 1 Héger-Bordet Street, 1000 Brussels, Belgium
2Université Libre de Bruxelles, 50 Franklin Roosevelt Avenue, 1050 Brussels, Belgium

Received 3 July 2014; Accepted 9 September 2014; Published 17 November 2014

Academic Editor: Nicolaas Lumen

Copyright © 2014 Fouad Aoun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Siegel, J. Ma, Z. Zou, and A. Jemal, “Cancer statistics, 2014,” CA: Cancer Journal for Clinicians, vol. 64, no. 1, pp. 9–29, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. C. J. Ryan, E. P. Elkin, E. J. Small, J. Duchane, and P. Carroll, “Reduced incidence of bony metastasis at initial prostate cancer diagnosis: data from CaPSURE,” Urologic Oncology, vol. 24, no. 5, pp. 396–402, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. M. A. Khan, M. Han, A. W. Partin, J. I. Epstein, and P. C. Walsh, “Long-term cancer control of radical prostatectomy in men younger than 50 years of age: update 2003,” Urology, vol. 62, no. 1, pp. 86–91, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. American Cancer Society, Cancer Facts and Figures 2013, American Cancer Society, Atlanta, Ga, USA, 2013.
  5. S. Hellman and R. R. J. Weichselbaum, “Oligometastases,” Journal of Clinical Oncology, vol. 13, no. 1, pp. 8–10, 1995. View at Google Scholar · View at Scopus
  6. E. Comen, L. Norton, and J. Massagué, “Clinical implications of cancer self-seeding,” Nature Reviews Clinical Oncology, vol. 8, no. 6, pp. 369–377, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Nitta and K. Sato, “Prognostic implications of the extent of surgical resection in patients with intracranial malignant gliomas,” Cancer, vol. 75, pp. 2727–2731, 1995. View at Google Scholar
  8. L. K. Temple, L. Hsieh, W. D. Wong, L. Saltz, and D. Schrag, “Use of surgery among elderly patients with stage IV colorectal cancer,” Journal of Clinical Oncology, vol. 22, no. 17, pp. 3475–3484, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. R. C. Flanigan, S. E. Salmon, B. A. Blumenstein et al., “Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer,” The New England Journal of Medicine, vol. 345, no. 23, pp. 1655–1659, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. G. H. J. Mickisch, A. Garin, H. van Poppel, L. de Prijck, and R. Sylvester, “Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: a randomised trial,” The Lancet, vol. 358, no. 9286, pp. 966–970, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Clarke, R. Collins, C. Davies, J. Godwin, R. Gray, and R. Peto, “Polychemotherapy for early breast cancer: an overview of the randomised trials,” The Lancet, vol. 352, no. 9132, pp. 930–942, 1998. View at Publisher · View at Google Scholar · View at Scopus
  12. O. Glehen, F. Mohamed, and F. N. Gilly, “Peritoneal carcinomatosis from digestive tract cancer: new management by cytoreductive surgery and intraperitoneal chemohyperthermia,” The Lancet Oncology, vol. 5, no. 4, pp. 219–228, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. R. E. Bristow, R. S. Tomacruz, D. K. Armstrong, E. L. Trimble, and F. J. Montz, “Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis,” Journal of Clinical Oncology, vol. 20, no. 5, pp. 1248–1259, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Bolla, D. Gonzalez, P. Warde et al., “Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin,” The New England Journal of Medicine, vol. 337, no. 5, pp. 295–300, 1997. View at Publisher · View at Google Scholar · View at Scopus
  15. M. V. Pilepich, R. Caplan, R. W. Byhardt et al., “Phase III trial of androgen suppression using goserelin in unfavorable-prognosis carcinoma of the prostate treated with definitive radiotherapy: report of Radiation Therapy Oncology Group protocol 85-31,” Journal of Clinical Oncology, vol. 15, no. 3, pp. 1013–1021, 1997. View at Google Scholar · View at Scopus
  16. M. Bolla, G. van Tienhoven, P. Warde et al., “External irradiation with or without long-term androgen suppression for prostate cancer with high metastatic risk: 10-year results of an EORTC randomised study,” The Lancet Oncology, vol. 11, no. 11, pp. 1066–1073, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. M. V. Pilepich, K. Winter, C. A. Lawton et al., “Androgen suppression adjuvant to definitive radiotherapy in prostate carcinoma—Long-term results of phase III RTOG 85-31,” International Journal of Radiation Oncology Biology Physics, vol. 61, no. 5, pp. 1285–1290, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Bria, F. Cuppone, D. Giannarelli et al., “Does hormone treatment added to radiotherapy improve outcome in locally advanced prostate cancer? Meta-analysis of randomized trials,” Cancer, vol. 115, no. 15, pp. 3446–3456, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. M. D. Shelley, S. Kumar, T. Wilt, J. Staffurth, B. Coles, and M. D. Mason, “A systematic review and meta-analysis of randomised trials of neo-adjuvant hormone therapy for localised and locally advanced prostate carcinoma,” Cancer Treatment Reviews, vol. 35, no. 1, pp. 9–17, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Heidenreich, P. J. Bastian, J. Bellmunt et al., “EAU guidelines on prostate cancer. Part II: treatment of advanced, relapsing, and castration-resistant prostate cancer,” European Urology, vol. 65, no. 2, pp. 467–479, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. D. Lim Joon, M. Hasegawa, C. Sikes et al., “Supraadditive apoptotic response of R3327-G rat prostate tumors to androgen ablation and radiation,” International Journal of Radiation Oncology Biology Physics, vol. 38, no. 5, pp. 1071–1077, 1997. View at Publisher · View at Google Scholar · View at Scopus
  22. F. H. Schroder, K. H. Kurth, S. D. Fossa et al., “Early versus delayed endocrine treatment of T2-T3 pN1-3 M0 prostate cancer without local treatment of the primary tumour: final results of European Organisation for the Research and Treatment of Cancer protocol 30846 after 13 years of follow-up (a randomised controlled trial),” European Urology, vol. 55, no. 1, pp. 14–22, 2009. View at Google Scholar
  23. A. Widmark, O. Klepp, A. Solberg et al., “Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial,” The Lancet, vol. 373, no. 9660, pp. 301–308, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Warde, M. Mason, K. Ding et al., “Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial,” The Lancet, vol. 378, no. 9809, pp. 2104–2111, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. N. Mottet, M. Peneau, J.-J. Mazeron, V. Molinie, and P. Richaud, “Addition of radiotherapy to long-term androgen deprivation in locally advanced prostate cancer: an open randomised phase 3 trial,” European Urology, vol. 62, no. 2, pp. 213–219, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. P. C. M. S. Verhagen, F. H. Schröder, L. Collette, and C. H. Bangma, “Does Local treatment of the prostate in advanced and/or lymph node metastatic disease improve efficacy of androgen-deprivation therapy? A systematic review,” European Urology, vol. 58, no. 2, pp. 261–269, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. P. B. Morgan, A. L. Hanlon, E. M. Horwitz, M. K. Buyyounouski, R. G. Uzzo, and A. Pollack, “Radiation dose and late failures in prostate cancer,” International Journal of Radiation Oncology Biology Physics, vol. 67, no. 4, pp. 1074–1081, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Engel, P. J. Bastian, H. Baur et al., “Survival benefit of radical prostatectomy in lymph node-positive patients with prostate cancer,” European Urology, vol. 57, no. 5, pp. 754–761, 2010. View at Publisher · View at Google Scholar
  29. R. Ghavamian, E. J. Bergstralh, M. L. Blute, J. Slezak, and H. Zincke, “Radical retropubic prostatectomy plus orchiectomy versus orchiectomy alone for pTxN+ prostate cancer: a matched comparison,” Journal of Urology, vol. 161, no. 4, pp. 1223–1228, 1999. View at Publisher · View at Google Scholar · View at Scopus
  30. T. Steuber, L. Budäus, J. Walz et al., “Radical prostatectomy improves progression-free and cancer-specific survival in men with lymph node positive prostate cancer in the prostate-specific antigen era: a confirmatory study,” BJU International, vol. 107, no. 11, pp. 1755–1761, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. G. P. Swanson, M. Riggs, and J. Earle, “Failure after primary radiation or surgery for prostate cancer: differences in response to androgen ablation,” Journal of Urology, vol. 172, no. 2, pp. 525–528, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. I. M. Thompson, C. Tangen, J. Basler, and E. D. Crawford, “Impact of previous local treatment for prostate cancer on subsequent metastatic disease,” Journal of Urology, vol. 168, no. 3, pp. 1008–1012, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. P. W. Kantoff, C. S. Higano, N. D. Shore et al., “Sipuleucel-T immunotherapy for castration-resistant prostate cancer,” The New England Journal of Medicine, vol. 363, no. 5, pp. 411–422, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. X.-J. Qin, C.-G. Ma, D.-W. Ye et al., “Tumor cytoreduction results in better response to androgen ablation—a preliminary report of palliative transurethral resection of the prostate in metastatic hormone sensitive prostate cancer,” Urologic Oncology: Seminars and Original Investigations, vol. 30, no. 2, pp. 145–149, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. S. H. Culp, P. F. Schellhammer, and M. B. Williams, “Might men diagnosed with metastatic prostate cancer benefit from definitive treatment of the primary tumor? A SEER-based study,” European Urology, vol. 65, no. 6, pp. 1058–1066, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Solberg, O. A. Haugen, T. Viset et al., “Residual prostate cancer in patients treated with endocrine therapy with or without radical radiotherapy: a side study of the SPCG-7 randomized trial,” International Journal of Radiation Oncology Biology Physics, vol. 80, no. 1, pp. 55–61, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. R. Khafagy, D. Shackley, J. Samuel, K. O'Flynn, C. Betts, and N. Clarke, “Complications arising in the final year of life in men dying from advanced prostate cancer,” Journal of Palliative Medicine, vol. 10, no. 3, pp. 705–711, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. C. A. Klein, D. Weckermann, B. Polzer et al., “Perioperative activation of disseminated tumor cells in bone marrow of patients with prostate cancer,” Journal of Clinical Oncology, vol. 27, no. 10, pp. 1549–1556, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. B. Psaila and D. Lyden, “The metastatic niche: adapting the foreign soil,” Nature Reviews Cancer, vol. 9, no. 4, pp. 285–293, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. C. Cai and S. P. Balk, “Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy,” Endocrine-Related Cancer, vol. 18, no. 5, pp. R175–R182, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Ahmed and L.-C. Li, “Adaptation and clonal selection models of castration-resistant prostate cancer: current perspective,” International Journal of Urology, vol. 20, no. 4, pp. 362–371, 2013. View at Publisher · View at Google Scholar · View at Scopus
  42. N. Craft, C. Chhor, C. Tran et al., “Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process,” Cancer Research, vol. 59, no. 19, pp. 5030–5036, 1999. View at Google Scholar · View at Scopus
  43. J. R. Gingrich, R. J. Barrios, M. W. Kattan, H. S. Nahm, M. J. Finegold, and N. M. Greenberg, “Androgen-independent prostate cancer progression in the TRAMP model,” Cancer Research, vol. 57, no. 21, pp. 4687–4691, 1997. View at Google Scholar · View at Scopus
  44. Z. Fuks, S. A. Leibel, K. E. Wallner et al., “The effect of local control on metastatic dissemination in carcinoma of the prostate: long-term results in patients treated with 1251 implantation,” International Journal of Radiation Oncology, Biology, Physics, vol. 21, no. 3, pp. 537–547, 1991. View at Publisher · View at Google Scholar · View at Scopus
  45. L. Resel Folkersma, L. San José Manso, I. Galante Romo, J. Moreno Sierra, and C. Olivier Gómez, “Prognostic significance of circulating tumor cell count in patients with metastatic hormone-sensitive prostate cancer,” Urology, vol. 80, no. 6, pp. 1328–1332, 2012. View at Publisher · View at Google Scholar · View at Scopus
  46. B. Fisher, N. Gunduz, J. Coyle, C. Rudock, and E. Saffer, “Presence of a growth-stimulating factor in serum following primary tumor removal in mice,” Cancer Research, vol. 49, no. 8, pp. 1996–2001, 1989. View at Google Scholar · View at Scopus
  47. G. N. Naumov, J. Folkman, O. Straume, and L. A. Akslen, “Tumor-vascular interactions and tumor dormancy,” APMIS, vol. 116, no. 7-8, pp. 569–585, 2008. View at Publisher · View at Google Scholar · View at Scopus
  48. W. Ceelen, P. Pattyn, and M. Mareel, “Surgery, wound healing, and metastasis: recent insights and clinical implications,” Critical Reviews in Oncology/Hematology, vol. 89, no. 1, pp. 16–26, 2014. View at Publisher · View at Google Scholar · View at Scopus
  49. P. A. Paraskeva, P. F. Ridgway, S. Olsen, C. Isacke, D. H. Peck, and A. W. Darzi, “A surgically induced hypoxic environment causes changes in the metastatic behaviour of tumours in vitro,” Clinical and Experimental Metastasis, vol. 23, no. 2, pp. 149–157, 2006. View at Publisher · View at Google Scholar · View at Scopus
  50. S. O. P. Hofer, G. Molema, R. A. E. C. Hermens, H. J. Wanebo, J. S. Reichner, and H. J. Hoekstra, “The effect of surgical wounding on tumour development,” European Journal of Surgical Oncology, vol. 25, no. 3, pp. 231–243, 1999. View at Publisher · View at Google Scholar · View at Scopus
  51. R. Abramovitch, M. Marikovsky, G. Meir, and M. Neeman, “Stimulation of tumour growth by wound-derived growth factors,” British Journal of Cancer, vol. 79, no. 9-10, pp. 1392–1398, 1999. View at Publisher · View at Google Scholar · View at Scopus
  52. M. P. M. Q. van Gils, D. Hessels, O. van Hooij et al., “The time-resolved fluorescence-based PCA3 test on urinary sediments after digital rectal examination; a Dutch multicenter validation of the diagnostic performance,” Clinical Cancer Research, vol. 13, no. 3, pp. 939–943, 2007. View at Publisher · View at Google Scholar · View at Scopus
  53. J. Folkman, “Angiogenesis in cancer, vascular, rheumatoid and other disease,” Nature Medicine, vol. 1, no. 1, pp. 27–31, 1995. View at Publisher · View at Google Scholar · View at Scopus
  54. R. Badwe, V. Parmar, R. Hawaldar et al., “Surgical removal of primary tumor and axillary lymph nodes in women with metastatic breast cancer at first presentation: a randomized controlled trial [abstract S2-02],” in Proceedings of the San Antonio Breast Cancer Symposium, San Antonio, Tex, USA, December 2013.
  55. R. L. Scodan, D. Stevens, E. Brain et al., “Breast cancer with synchronous metastases: survival Impact of exclusive locoregional radiotherapy,” Journal of Clinical Oncology, vol. 27, no. 9, pp. 1375–1381, 2009. View at Publisher · View at Google Scholar · View at Scopus
  56. M. C. Haffner, T. Mosbruger, D. M. Esopi et al., “Tracking the clonal origin of lethal prostate cancer,” Journal of Clinical Investigation, vol. 123, no. 11, pp. 4918–4922, 2013. View at Publisher · View at Google Scholar · View at Scopus
  57. D. Singh, W. S. Yi, R. A. Brasacchio et al., “Is there a favorable subset of patients with prostate cancer who develop oligometastases?” International Journal of Radiation Oncology Biology Physics, vol. 58, no. 1, pp. 3–10, 2004. View at Publisher · View at Google Scholar · View at Scopus
  58. “The site of visceral metastases to predict overall survival in castration-resistant prostate cancer patients: a meta-analysis of five phase III trials,” Journal of Clinical Oncology, vol. 32, abstract 5002, p. 5s, 2014.
  59. F. D. Birkhäuser, U. E. Studer, J. M. Froehlich et al., “Combined ultrasmall superparamagnetic particles of iron oxide-enhanced and diffusion-weighted magnetic resonance imaging facilitates detection of metastases in normal-sized pelvic lymph nodes of patients with bladder and prostate cancer,” European Urology, vol. 64, no. 6, pp. 953–960, 2013. View at Publisher · View at Google Scholar · View at Scopus
  60. M. R. Bashir, L. Bhatti, D. Marin, and R. C. Nelson, “Emerging applications for ferumoxytol as a contrast agent in MRI,” Journal of Magnetic Resonance Imaging, 2014. View at Google Scholar
  61. A. Afshar-Oromieh, C. M. Zechmann, A. Malcher et al., “Comparison of PET imaging with a 68Ga-labelled PSMA ligand and 18F-choline-based PET/CT for the diagnosis of recurrent prostate cancer,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 41, no. 1, pp. 11–20, 2014. View at Publisher · View at Google Scholar · View at Scopus
  62. P. B. Zanzonico, R. Finn, K. S. Pentlow et al., “PET-based radiation dosimetry in man of 18F- fluorodihydrotestosterone, a new radiotracer for imaging prostate cancer,” Journal of Nuclear Medicine, vol. 45, no. 11, pp. 1966–1971, 2004. View at Google Scholar · View at Scopus
  63. K. Beiderwellen, M. Huebner, P. Heusch et al., “Whole-body [18F]FDG PET/MRI versus PET/CT in the assessment of bone lesions in oncological patients: initial results,” European Radiology, vol. 24, no. 8, pp. 2023–2030, 2014. View at Publisher · View at Google Scholar · View at Scopus
  64. U. Schick, S. Jorcano, P. Nouet et al., “Androgen deprivation and high-dose radiotherapy for oligometastatic prostate cancer patients with less than five regional and/or distant metastases,” Acta Oncologica, vol. 52, no. 8, pp. 1622–1628, 2013. View at Publisher · View at Google Scholar · View at Scopus
  65. Y. Fong, J. Fortner, R. L. Sun, M. F. Brennan, and L. H. Blumgart, “Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases,” Annals of Surgery, vol. 230, no. 3, pp. 309–321, 1999. View at Publisher · View at Google Scholar · View at Scopus
  66. U. Pastorino, M. Buyse, G. Friedel et al., “Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases,” Journal of Thoracic and Cardiovascular Surgery, vol. 113, no. 1, pp. 37–49, 1997. View at Publisher · View at Google Scholar · View at Scopus
  67. V. E. Strong, M. D'Angelica, L. Tang et al., “Laparoscopic adrenalectomy for isolated adrenal metastasis,” Annals of Surgical Oncology, vol. 14, no. 12, pp. 3392–3400, 2007. View at Publisher · View at Google Scholar · View at Scopus
  68. Y. Furuya, K. Akakura, S. Akimoto, H. Inomiya, and H. Ito, “Pattern of progression and survival in hormonally treated metastatic prostate cancer,” International Journal of Urology, vol. 6, no. 5, pp. 240–244, 1999. View at Publisher · View at Google Scholar · View at Scopus
  69. L. Potters, B. Kavanagh, J. M. Galvin et al., “American Society for Therapeutic Radiology and Oncology (ASTRO) and American College of Radiology (ACR) practice guideline for the performance of stereotactic body radiation therapy,” International Journal of Radiation Oncology Biology Physics, vol. 76, no. 2, pp. 326–332, 2010. View at Publisher · View at Google Scholar · View at Scopus
  70. C. Greco, M. J. Zelefsky, M. Lovelock et al., “Predictors of local control after single-dose stereotactic image-guided intensity-modulated radiotherapy for extracranial metastases,” International Journal of Radiation Oncology Biology Physics, vol. 79, no. 4, pp. 1151–1157, 2011. View at Publisher · View at Google Scholar · View at Scopus
  71. B. A. Jereczek-Fossa, L. Fariselli, G. Beltramo et al., “Linac-based or robotic image-guided stereotactic radiotherapy for isolated lymph node recurrent prostate cancer,” Radiotherapy and Oncology, vol. 93, no. 1, pp. 14–17, 2009. View at Publisher · View at Google Scholar · View at Scopus
  72. B. A. Jereczek-Fossa, G. Beltramo, L. Fariselli et al., “Robotic image-guided stereotactic radiotherapy, for isolated recurrent primary, lymph node or metastatic prostate cancer,” International Journal of Radiation Oncology Biology Physics, vol. 82, no. 2, pp. 889–897, 2012. View at Publisher · View at Google Scholar · View at Scopus
  73. F. Casamassima, L. Masi, C. Menichelli et al., “Efficacy of eradicative radiotherapy for limited nodal metastases detected with choline PET scan in prostate cancer patients,” Tumori, vol. 97, no. 1, pp. 49–55, 2011. View at Publisher · View at Google Scholar · View at Scopus
  74. A. Muacevic, M. Kufeld, C. Rist, B. Wowra, C. Stief, and M. Staehler, “Safety and feasibility of image-guided robotic radiosurgery for patients with limited bone metastases of prostate cancer,” Urologic Oncology: Seminars and Original Investigations, vol. 31, no. 4, pp. 455–460, 2013. View at Publisher · View at Google Scholar · View at Scopus
  75. P. Berkovic, G. De Meerleer, L. Delrue et al., “Salvage stereotactic body radiotherapy for patients with limited prostate cancer metastases: deferring androgen deprivation therapy,” Clinical Genitourinary Cancer, vol. 11, no. 1, pp. 27–32, 2013. View at Publisher · View at Google Scholar · View at Scopus
  76. K. Decaestecker, G. De Meerleer, B. Lambert et al., “Repeated stereotactic body radiotherapy for oligometastatic prostate cancer recurrence,” Radiation Oncology, vol. 9, pp. 135–145, 2014. View at Google Scholar
  77. K. A. Ahmed, B. M. Barney, B. J. Davis, S. S. Park, E. D. Kwon, and K. R. Olivier, “Stereotactic body radiation therapy in the treatment of oligometastatic prostate cancer,” Frontiers in Oncology, vol. 2, article 215, 2013. View at Publisher · View at Google Scholar · View at Scopus
  78. K. S. Corbin, S. Hellman, and R. R. Weichselbaum, “Extracranial oligometastases: a subset of metastases curable with stereotactic radiotherapy,” Journal of Clinical Oncology, vol. 31, no. 11, pp. 1384–1390, 2013. View at Publisher · View at Google Scholar · View at Scopus
  79. Y. A. Lussier, H. R. Xing, J. K. Salama et al., “MicroRNA expression characterizes oligometastasis(es),” PLoS ONE, vol. 6, no. 12, Article ID e28650, 2011. View at Publisher · View at Google Scholar
  80. J. L. Gulley, P. M. Arlen, A. Bastian et al., “Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer,” Clinical Cancer Research, vol. 11, no. 9, pp. 3353–3362, 2005. View at Publisher · View at Google Scholar · View at Scopus
  81. Y. Wang, G. Yang, Y. Y. Wang, J. L. Yang, and K. Yang, “Early efficacy of stereotactic body radiation therapy combined with adoptive immunotherapy for advanced malignancies,” Molecular and Clinical Oncology, vol. 1, no. 5, pp. 925–929, 2013. View at Google Scholar
  82. Y.-Y. Wang, Y.-S. Wang, T. Liu et al., “Efficacy study of CyberKnife stereotactic radiosurgery combined with CIK cell immunotherapy for advanced refractory lung cancer,” Experimental and Therapeutic Medicine, vol. 5, no. 2, pp. 453–456, 2013. View at Publisher · View at Google Scholar · View at Scopus
  83. S. J. Freedland, E. B. Humphreys, L. A. Mangold et al., “Risk of prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy,” Journal of the American Medical Association, vol. 294, no. 4, pp. 433–439, 2005. View at Publisher · View at Google Scholar · View at Scopus
  84. M. Colombié, C. Bailly, and D. Rusu, “18F-Fluorocholine PET/CT in therapeutic strategy of biochemical recurrent prostate cancer: a retrospective study of 200 patients,” The Journal of Nuclear Medicine, vol. 55, no. 1, pp. 1656–1661, 2014. View at Google Scholar
  85. A. Briganti, J. R. Karnes, L. F. da Pozzo et al., “Two positive nodes represent a significant cut-off value for cancer specific survival in patients with node positive prostate cancer: a new proposal based on a two- institution experience on 703 consecutive N+ patients treated with radical prostatectomy, extended pelvic lymph node dissection and adjuvant therapy,” European Urology, vol. 55, no. 2, pp. 261–270, 2009. View at Publisher · View at Google Scholar · View at Scopus
  86. C. van Praet, P. Ost, N. Lumen et al., “Postoperative high-dose pelvic radiotherapy for N+ prostate cancer: toxicity and matched case comparison with postoperative prostate bed-only radiotherapy,” Radiotherapy and Oncology, vol. 109, no. 2, pp. 222–228, 2013. View at Publisher · View at Google Scholar · View at Scopus
  87. J. Ji, H. Yuan, L. Wang, and J. Hou, “Is the impact of the extent of lymphadenectomy in radical prostatectomy related to the disease risk? A single center prospective study,” Journal of Surgical Research, vol. 178, no. 2, pp. 779–784, 2012. View at Publisher · View at Google Scholar · View at Scopus
  88. F. Kunath, B. Keck, G. Rücker et al., “Early versus deferred androgen suppression therapy for patients with lymph node-positive prostate cancer after local therapy with curative intent: a systematic review,” BMC Cancer, vol. 13, article 131, 2013. View at Publisher · View at Google Scholar · View at Scopus
  89. Y.-N. Wong, S. Freedland, B. Egleston, G. Hitdes, J. S. Schwartz, and K. Armstrong, “Role of androgen deprivation therapy for node-positive prostate cancer,” Journal of Clinical Oncology, vol. 27, no. 1, pp. 100–105, 2009. View at Publisher · View at Google Scholar · View at Scopus
  90. W. Dale, J. Hemmerich, K. Bylow, S. Mohile, M. Mullaney, and W. M. Stadler, “Patient anxiety about prostate cancer independently predicts early initiation of androgen deprivation therapy for biochemical cancer recurrence in older men: a prospective cohort study,” Journal of Clinical Oncology, vol. 27, no. 10, pp. 1557–1563, 2009. View at Publisher · View at Google Scholar · View at Scopus
  91. F. Schröder, C. Bangma, J. C. Angulo et al., “Dutasteride treatment over 2 years delays prostate-specific antigen progression in patients with biochemical failure after radical therapy for prostate cancer: results from the randomised, placebo-controlled avodart after radical therapy for Prostate Cancer Study (ARTS),” European Urology, vol. 63, no. 5, pp. 779–787, 2013. View at Publisher · View at Google Scholar · View at Scopus
  92. C. A. Jilg, H. C. Rischke, S. N. Reske et al., “Salvage lymph node dissection with adjuvant radiotherapy for nodal recurrence of prostate cancer,” Journal of Urology, vol. 188, no. 6, pp. 2190–2197, 2012. View at Publisher · View at Google Scholar · View at Scopus
  93. L. Rinnab, F. M. Mottaghy, J. Simon et al., “[11C]choline PET/CT for targeted salvage lymph node dissection in patients with biochemical recurrence after primary curative therapy for prostate cancer: preliminary results of a prospective study,” Urologia Internationalis, vol. 81, no. 2, pp. 191–197, 2008. View at Publisher · View at Google Scholar · View at Scopus
  94. D. Schilling, H. P. Schlemmer, P. H. Wagner et al., “Histological verification of 11C-choline-positron emission/computed tomography-positive lymph nodes in patients with biochemical failure after treatment for localized prostate cancer,” BJU International, vol. 102, no. 4, pp. 446–451, 2008. View at Publisher · View at Google Scholar · View at Scopus
  95. F. Abdollah, A. Briganti, F. Montorsi et al., “Contemporary role of salvage lymphadenectomy in patients with recurrence following radical prostatectomy,” European Urology, 2014. View at Publisher · View at Google Scholar · View at Scopus
  96. A. Winter, J. Uphoff, R.-P. Henke, and F. Wawroschek, “First results of [11C]choline PET/CT-guided secondary lymph node surgery in patients with PSA failure and single lymph node recurrence after radical retropubic prostatectomy,” Urologia Internationalis, vol. 84, no. 4, pp. 418–423, 2010. View at Publisher · View at Google Scholar · View at Scopus
  97. N. M. Passoni, N. Suardi, F. Abdollah et al., “Utility of [11C]choline PET/CT in guiding lesion-targeted salvage therapies in patients with prostate cancer recurrence localized to a single lymph node at imaging: results from a pathologically validated series,” Urologic Oncology: Seminars and Original Investigations, vol. 32, no. 1, pp. 38–e16, 2014. View at Publisher · View at Google Scholar · View at Scopus
  98. D. Tilki, O. Reich, A. Graser et al., “18F-fluoroethylcholine PET/CT identifies lymph node metastasis in patients with prostate-specific antigen failure after radical prostatectomy but underestimates its extent,” European Urology, vol. 63, no. 5, pp. 792–796, 2013. View at Publisher · View at Google Scholar · View at Scopus
  99. P. Rigatti, N. Suardi, A. Briganti et al., “Pelvic/retroperitoneal salvage lymph node dissection for patients treated with radical prostatectomy with biochemical recurrence and nodal recurrence detected by [11C]choline positron emission tomography/computed tomography,” European Urology, vol. 60, no. 5, pp. 935–943, 2011. View at Publisher · View at Google Scholar · View at Scopus
  100. N. Suardi, G. Gandaglia, A. Gallina et al., “Long-term outcomes of salvage lymph node dissection for clinically recurrent prostate cancer: results of a single-institution series with a minimum follow-up of 5 years,” European Urology, 2014. View at Publisher · View at Google Scholar · View at Scopus
  101. N. Suardi, J. Karnes, S. Joniau et al., “Salvage lymph node dissection for patients treated with radical prostatectomy with biochemical recurrence and imaging-detected nodal metastases,” Journal of Urology, vol. 189, pp. 317–318, 2013. View at Publisher · View at Google Scholar