Research Article
Endocannabinoid Receptors Gene Expression in Morbidly Obese Women with Nonalcoholic Fatty Liver Disease
Table 1
Characteristics of study cohort classified according to the liver pathology.
| | Morbidly Obese () | | NL () | SS () | NASH () | | Mean ± SD | Mean ± SD | Mean ± SD |
| Age (years) | 44.0 ± 3.2 | 47.4 ± 1.5 | 45.9 ± 1.4 | Weight (kg) | 121.0 ± 12.1 | 121.8 ± 16.3 | 123.8 ± 14.3 | WC (cm) | 129.5 ± 6.4 | 132.1 ± 10.7 | 135.1 ± 9.9 | BMI (kg/m2) | 48.6 ± 2.6 | 48.1 ± 7.8 | 47.5 ± 5.4 | Glucose (mg/dL) | 101.8 ± 18.9 | 125.4 ± 38.2 | 119.0 ± 30.0 | Insulin (mUI/L) | 11.4 ± 3.1 | 21.2 ± 11.5 | 23.1 ± 28.1 | HbA1c (%) | 4.3 ± 0.3 | 5.9 ± 1.7 | 5.8 ± 1.7 | HOMA2-IR | 1.5 ± 0.5 | 2.9 ± 1.4 | 3.0 ± 3.4 | HDL-C (mg/dL) | 43.6 ± 7.6 | 39.3 ± 9.5 | 41.5 ± 9.0 | LDL-C (mg/dL) | 102.0 ± 31.7 | 104.7 ± 24.6 | 102.5 ± 32.6 | Triglycerides (mg/dL) | 144.4 ± 51.9 | 178.4 ± 68.5 | 183.1 ± 86.6 | AST (U/L) | 25.8 ± 8.5 | 43.7 ± 34.4* | 44.9 ± 29.3* | ALT (U/L) | 25.4 ± 10.5 | 45.6 ± 31.6* | 46.3 ± 28.3* | GGT (U/L) | 18.3 ± 13.8 | 30.6 ± 22.2 | 36.1 ± 31.7 | ALP (U/L) | 58.2 ± 12.6 | 66.3 ± 16.0 | 71.9 ± 15.2* | Adipocytokine levels | | | | Adiponectin (µg/mL) | 10.1 ± 2.0 | 6.8 ± 3.5 | 6.7 ± 2.4 | IL6 (pg/mL) | 2.1 ± 0.6 | 2.9 ± 2.5 | 3.3 ± 2.0 | Resistin (ng/mL) | 5.1 ± 2.1 | 4.6 ± 2.0 | 4.5 ± 1.6 | TNFRII (ng/mL) | 4.2 ± 1.4 | 5.5 ± 2.5 | 5.6 ± 1.7 | CRP (mg/dL) | 1.0 ± 0.8 | 0.9 ± 0.7 | 1.1 ± 0.7 |
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NL: morbidly obese subjects with normal liver; SS: morbidly obese subjects with simple steatosis; NASH: morbidly obese subjects with steatohepatitis; ALT: alanine aminotransferase; ALP: alkaline phosphatase; AST: aspartate aminotransferase; BMI: body mass index; CRP: C-reactive protein; GGT: gamma-glutamyltransferase; HbA1c: glycosylated haemoglobin; HDL-C: high density lipoprotein; HOMA2-IR: homeostatic model assessment 2-insulin resistance; IL6: interleukin 6; LDL-C: low density lipoprotein; TNFRII: tumour necrosis factor receptor II; WC: waist circumference. indicates significant differences respect NL group ().
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