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BioMed Research International
Volume 2014, Article ID 503634, 12 pages
Review Article

Noncoding RNAs: Emerging Players in Muscular Dystrophies

1Institute of Cell Biology and Neurobiology, National Research Council, 00015 Monterotondo Scalo, Italy
2Policlinico San Donato-IRCCS, Molecular Cardiology Laboratory, 20097 San Donato Milanese, Milan , Italy

Received 5 December 2013; Accepted 17 January 2014; Published 4 March 2014

Academic Editor: Akinori Nakamura

Copyright © 2014 Germana Falcone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The fascinating world of noncoding RNAs has recently come to light, thanks to the development of powerful sequencing technologies, revealing a variety of RNA molecules playing important regulatory functions in most, if not all, cellular processes. Many noncoding RNAs have been implicated in regulatory networks that are determinant for skeletal muscle differentiation and disease. In this review, we outline the noncoding RNAs involved in physiological mechanisms of myogenesis and those that appear dysregulated in muscle dystrophies, also discussing their potential use as disease biomarkers and therapeutic targets.