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BioMed Research International
Volume 2014, Article ID 505987, 9 pages
Research Article

Enhanced Analgesic Properties and Reduced Ulcerogenic Effect of a Mononuclear Copper(II) Complex with Fenoprofen in Comparison to the Parent Drug: Promising Insights in the Treatment of Chronic Inflammatory Diseases

1INQUISUR, Departamento de Química, Universidad Nacional del Sur, Avenida Alem 1253, B8000CPB Bahía Blanca, Argentina
2Laboratorio de Toxicología, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, B8000CPB Bahía Blanca, Argentina
3Centro de Investigación y Desarrollo de Fármacos (CIDEF), Facultad de Ciencias Veterinarias, Universidad Nacional de La Pampa, Calle 5 y 116, 6360 General Pico, Argentina

Received 17 February 2014; Revised 12 May 2014; Accepted 27 May 2014; Published 19 June 2014

Academic Editor: Abdel A. Abdel-Rahman

Copyright © 2014 Mariela Agotegaray et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [4 citations]

The following is the list of published articles that have cited the current article.

  • Simphiwe Mavuso, Yahya E. Choonara, Thashree Marimuthu, Pradeep Kumar, Lisa C. du Toit, Pierre P.D. Kondiah, and Viness Pillay, “A Dual pH/Redox Responsive Copper-Ligand Nanoliposome Bioactive Complex for the Treatment of Chronic Inflammation,” International Journal of Pharmaceutics, 2016. View at Publisher · View at Google Scholar
  • Anthony C. Johnson, and Beverley Greenwood-Van Meerveld, “Critical Evaluation of Animal Models of Gastrointestinal Disorders,” 2017. View at Publisher · View at Google Scholar
  • Norma Rodríguez-Laguna, Luis Ignacio Reyes-García, Raúl Pacheco-Gómez, Raúl Flores, Alberto Rojas-Hernández, and Rodolfo Gómez-Balderas, “Thermodynamic study of complexation of Zn(II)/L (L− = acetate, indomethacin and diclofenac anions) by isothermal titration calorimetry,” Journal of Thermal Analysis and Calorimetry, 2018. View at Publisher · View at Google Scholar
  • Halil Ilkimen, Yasemin Tekşen, Cengiz Yenikaya, Irem Turhan, Tuncay Tunç, and Musa Sari, “Synthesis, characterization, and pharmacological evaluation of the proton transfer salts of 2-aminobenzothiazole derivatives with 5-sulfosalicylic acid and their Cu(II) complexes,” Journal of Coordination Chemistry, pp. 1–12, 2018. View at Publisher · View at Google Scholar