Differential Hypermethylation of Death-Associated Protein Kinase Promoter in Central Neurocytoma and Oligodendroglioma

Table 1

Summary of the results of DAPK protein expression in central neurocytoma and oligodendroglioma.

Type of tumor	DAPK protein expression		𝑃
	Low	High
Central neurocytoma (𝑛=13)	8	5	0.054
Oligodendroglioma (𝑛=10)	1	9

DAPK protein expression in the formalin-fixed, paraffin-embedded sections from central neurocytoma and oligodendroglioma was determined by two parameters, that is, the extent of tumor cells and the intensity of immunoreactivity. A numerical grade (0–3) from each parameter was assigned to every section, and the product of the two numbers was used to assess the level of DAPK protein expression as described in Section 2. A final score of <4 in a sample was considered as low DAPK expression, while a score of ≥4 was regarded as high DAPK expression. No statistically significant difference was found in the distribution of DAPK protein expression between central neurocytoma and oligodendroglioma.