Differential Hypermethylation of Death-Associated Protein Kinase Promoter in Central Neurocytoma and Oligodendroglioma

Table 2

Correlation between DAPK protein expression and DAPK promoter hypermethylation in combined central neurocytoma and oligodendroglioma samples.

DAPK protein expression	Methylation status		𝑃
	−	+
Low (𝑛=9)	0	9	0.002
High (𝑛=14)	11	3

DAPK protein expression and DAPK promotor hypermethylation were determined as described in Section 2. Results obtained from both the central neurocytoma and oligodendroglioma samples were combined in this analysis. In 9 out of 9 cases (100%), low levels of DAPK protein expression exhibited high levels of DAPK promoter hypermethylation. In contrast, in samples with high levels of DAPK protein expression, only 21.4% (3 out of 14 cases) showed high levels of DAPK promoter hypermethylation. These results showed the DAPK protein expression and DAPK promoter hypermethylation correlated inversely in the cohort of 23 patients (𝑃=0.002).