FSim: A Novel Functional Similarity Search Algorithm and Tool for Discovering Functionally Related Gene Products

Figure 5

The ROC curve for the performance comparison of different algorithms using the p53 signaling pathway as an exemplary evaluation data set. The AUC value for FSim in the P53 pathway is 0.89, compared with 0.74, 0.83, 0.83, 0.85, and 0.62 for DAVID, funSimMax. Lin, funSimMax.relevance, dot.relevance, and hausdorff.relevance, respectively.