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BioMed Research International
Volume 2014, Article ID 509204, 9 pages
http://dx.doi.org/10.1155/2014/509204
Review Article

Laboratory Markers of Ventricular Arrhythmia Risk in Renal Failure

Department of Functional Sciences, “Victor Babes” University of Medicine and Pharmacy, T. Vladimirescu Street 14, 300173 Timisoara, Romania

Received 28 February 2014; Revised 21 April 2014; Accepted 22 April 2014; Published 26 May 2014

Academic Editor: Patrizia Cardelli

Copyright © 2014 Ioana Mozos. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sudden cardiac death continues to be a major public health problem. Ventricular arrhythmia is a main cause of sudden cardiac death. The present review addresses the links between renal function tests, several laboratory markers, and ventricular arrhythmia risk in patients with renal disease, undergoing or not hemodialysis or renal transplant, focusing on recent clinical studies. Therapy of hypokalemia, hypocalcemia, and hypomagnesemia should be an emergency and performed simultaneously under electrocardiographic monitoring in patients with renal failure. Serum phosphates and iron, PTH level, renal function, hemoglobin and hematocrit, pH, inflammatory markers, proteinuria and microalbuminuria, and osmolarity should be monitored, besides standard 12-lead ECG, in order to prevent ventricular arrhythmia and sudden cardiac death.