BioMed Research International

BioMed Research International / 2014 / Article
Special Issue

Novelties in the Anatomy of the Central Nervous System and Related Disorders

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Editorial | Open Access

Volume 2014 |Article ID 514974 |

Branislav Filipović, Nevena Radonjic, Igor Jakovcevski, Milos Petrovic, "Novelties in the Anatomy of the Central Nervous System and Related Disorders", BioMed Research International, vol. 2014, Article ID 514974, 2 pages, 2014.

Novelties in the Anatomy of the Central Nervous System and Related Disorders

Received28 May 2014
Accepted28 May 2014
Published15 Jun 2014

Anatomy of the central nervous system (CNS) is far beyond the classical approach to anatomy investigations. Studies of the CNS are, nowadays, comprising various fields of medicine, starting from clinical investigations, up to the animal models, so they are useful in studies of different neuropsychiatric diseases and disorders, such as schizophrenia, posttraumatic stress syndrome, and Alzheimer’s disease. Serious investigations in the field of the CNS are inseparable from the technological advances in the research, but also in diagnostics. This is the reason why we have gathered, at a glance, the papers that have very little in common. But the file rouge is the anatomy of the CNS and its changes illustrated in this unity in differences. Our initial aim was to illustrate the importance of the knowledge of CNS anatomy, for either the investigators in this field or the clinicians, devoted to solving the problem of serious neuropsychiatric diseases.

Two papers are dealing with the effects of maternal deprivation on rats brains. Maternal deprivation represents widely used animal model of schizophrenia and it is based on the 24 hr separation of the 9-day-old offspring from their mother. The rats were sacrificed in early adult period. Dr. M. Aksić and his team revealed that maternally deprived rats had a 28% smaller cell soma area in the prefrontal cortex, (30% in retrosplenial cortex), and 15% in motor cortex compared to the controls. Using the same model, Dr. B. Marković and coauthors outlined the significant decrease in the activity of acetylcholine esterase in the cortex and increase in the hippocampus of maternally deprived rats.

Dr. M. Kutová and coworkers are claiming that gross postmortem changes in the planum temporale in Alzheimer’s disease may be at least partially attributed to neurohistological changes in the layer III pyramidal neurons.

An interesting study of hypothalamopituitary-adrenocortical role in the hyperthermia has been conducted by Tseng et al. Their results suggest that human umbilical cord blood-derived stem cells therapy may improve outcomes of heatstroke in mice by reducing systemic inflammation as well as hypothalamopituitary-adrenocortical axis impairment.

A clinical study of posttraumatic stress disorder (PTSD), presented by Dr. A. Starcevic et al., demonstrates a significant reduction in the volumes of amygdala in the left hemisphere in the PTSD patients, suggesting the eventual role of amygdaloid complex in this disease.

All presented papers show the interest of the investigators of different kinds in the anatomy of the CNS and its change in different conditions, in the animals in the experimental models, postmortem human brains, or PTSD patients. With the advances in knowledge of the CNS anatomy structures, perhaps their role in the pathogenesis of diseases and disorders of different origin is going to be, even partially, clarified.

Branislav Filipović
Nevena Radonjic
Igor Jakovcevski
Milos Petrovic

Copyright © 2014 Branislav Filipović et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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