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BioMed Research International
Volume 2014, Article ID 517125, 9 pages
Clinical Study

New Tools for Embryo Selection: Comprehensive Chromosome Screening by Array Comparative Genomic Hybridization

1IVIOMICS SPAIN, Parc Cientific Universitat de València, Calle Catedrático Agustín Escardino 9, 46980 Valencia, Spain
2Instituto Valenciano de Infertilidad (IVI), Instituto Universitario IVI/INCLIVA, Plaza de la Policía Local 3, 46015 Valencia, Spain
3IVIOMICS USA, 1200 NW 78th Avenue, Suite 103, Miami, FL 33126, USA
4IVIOMICS INDIA, 13 Olof Palme Marg, Vasant Vihar, New Delhi 11057, India
5Fundación IVI, 46980 Valencia, Spain
6Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA

Received 12 January 2014; Accepted 24 February 2014; Published 29 April 2014

Academic Editor: Irma Virant-Klun

Copyright © 2014 Lorena Rodrigo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objective of this study was to evaluate the usefulness of comprehensive chromosome screening (CCS) using array comparative genomic hybridization (aCGH). The study included 1420 CCS cycles for recurrent miscarriage ( ); repetitive implantation failure ( ); severe male factor ( ); previous trisomic pregnancy ( ); and advanced maternal age ( ). CCS was performed in cycles with fresh oocytes and embryos ( ); mixed cycles with fresh and vitrified oocytes ( ); mixed cycles with fresh and vitrified day-2 embryos ( ); and mixed cycles with fresh and vitrified day-3 embryos ( ). Day-3 embryo biopsy was performed and analyzed by aCGH followed by day-5 embryo transfer. Consistent implantation (range: 40.5–54.2%) and pregnancy rates per transfer (range: 46.0–62.9%) were obtained for all the indications and independently of the origin of the oocytes or embryos. However, a lower delivery rate per cycle was achieved in women aged over 40 years (18.1%) due to the higher percentage of aneuploid embryos (85.3%) and lower number of cycles with at least one euploid embryo available per transfer (40.3%). We concluded that aneuploidy is one of the major factors which affect embryo implantation.