New Tools for Embryo Selection: Comprehensive Chromosome Screening by Array Comparative Genomic Hybridization
Table 1
Clinical results of 1420 CCS cycles according to the origin of the oocytes and embryos.
Fresh cycles
Mixed vitrified oocytes
Mixed day-2 vitrified embryos
Mixed day-3 vitrified embryos
Number of cycles
774
320
235
91
Mean female age (SD)
39.4 (3.2)
39.7 (3.9)
38.9 (3.5)
38.3 (3.4)
Mean number of embryos analyzed (SD)
4.7 (2.9)b,c
5.0 (2.7)a,d,c
6.4 (3.4)a,b,d
4.4 (2.7)b,c
Number of informative embryos
3573
1565
1499
481
Total number of aneuploid embryos (%)
2757 (77.2)
1248 (79.7)
1151 (76.8)
371 (77.1)
Number of segmental aneuploidies (%)
151 (4.2)
51 (3.2)
56 (3.7)
20 (4.1)
Number of embryos with a chaotic pattern (%)
561 (15.7)
250 (16.0)
204 (13.6)
53 (11.0)
Number of embryos with >1 aneuploidy (%)
1191 (33.3)
578 (36.9)d
485 (32.3)
144 (29.9)b
Number of embryo transfers (%)
421 (54.4)
156 (48.7)c
147 (62.5)b
59 (64.8)
Mean transferred embryos (SD)
1.4 (0.5)
1.4 (0.5)
1.5 (0.5)
1.5 (0.5)
Number of pregnancies/transfer (%)
225 (53.4)
93 (59.6)
71 (48.3)
29 (49.1)
Number of pregnancies/cycle (%)
225 (29.1)
93 (29.1)
71 (30.2)
29 (31.9)
Implantation rate
48.1
51.9
40.0
43.7
Miscarriage rate
6.6 (15/225)
8.6 (8/93)
8.4 (6/71)
6.9 (2/29)
Delivery rate/cycle
27.1 (210)
26.6 (85)
27.7 (65)
29.7 (27)
versus fresh cycles; b versus mixed vitrified oocytes; c versus mixed day-2 vitrified embryos; d versus mixed day-3 vitrified embryos. Chi-square test, Fisher exact test, or Welch -test with Bonferroni’s correction.
