New Tools for Embryo Selection: Comprehensive Chromosome Screening by Array Comparative Genomic Hybridization

Table 2

Clinical results of 1420 CCS cycles according to the different indications.

	RM <40 yrs	RIF <40 yrs	PTP <40 yrs	MF <40 yrs	AMA ≥40 yrs
Number of cycles	203	188	33	116	880
Mean female age (SD)	35.9 (2.7)	36.5 (2.5)	36.8 (2.4)	34.8 (3.2)	41.5 (2.1)
Mean number of embryos analyzed (SD)	5.5 (3.1)^b,d,e	5.9 (3.0)^a,d,e	5.7 (3.8)^d,e	6.8 (3.7)^a,b,c,e	4.6 (2.6)^a,b,c,d
Number of informative embryos	1099	1064	186	797	3972
Total number of aneuploid embryos (%)	750 (68.2)^e	720 (67.7)^e	133 (71.5)^e	521 (65.4)^e	3403 (85.3)^a,b,c,d
Number of segmental aneuploidies (%)	61 (5.5)^e	40 (3.7)^c	19 (10.2)^b,d,e	32 (4.0)^c	126 (3.2)^a,c
Number of embryos with a chaotic pattern (%)	180 (16.4)^b	119 (11.2)^a,e	24 (12.9)	125 (15.5)	620 (15.6)^b
Number of embryos with >1 aneuploidy (%)	237 (21.6)^e	250 (23.5)^e	41 (22.0)^e	158 (19.8)^e	1711 (43.1)^a,b,c,d
Number of embryo transfers (%)	157 (77.3)^e	149 (79.2)^e	26 (78.8)^e	97 (83.6)^e	354 (40.3)^a,b,c,d
Mean transferred embryos (SD)	1.5 (0.5)	1.5 (0.6)	1.4 (0.5)	1.5 (0.5)	1.3 (0.5)
Number of pregnancies/transfer (%)	90 (57.3)	85 (57.0)	12 (46.0)	61 (62.9)	170 (48.0)
Number of pregnancies/cycle (%)	90 (44.3)^e	85 (45.2)^e	12 (36.4)	61 (52.1)^e	170 (19.3)^a,b,d
Implantation rate	47.9	50.9	40.5	54.2	42.4
Miscarriage rate	13.3	4.7	16.7	3.3	6.5
Delivery rate/cycle	38.4 (78)^e	43.1 (81)^e	30.3 (10)	50.9 (59)^e	18.1 (159)^a,b,d

RM: recurrent miscarriage; RIF: repetitive implantation failure; MF: severe male factor; PTP: previous trisomic pregnancy; AMA: advanced maternal age.
^a𝑃<0.05 versus RM <40 yrs; ^b𝑃<0.05 versus RIF <40 yrs; ^c𝑃<0.05 versus PTP <40 yrs; ^d𝑃<0.05 versus MF <40 yrs; ^e𝑃<0.05 versus AMA ≥40 yrs. Chi-square test, Fisher exact test, or Welch 𝑡-test with Bonferroni’s correction.