Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 521380, 11 pages
http://dx.doi.org/10.1155/2014/521380
Review Article

Significance of Chromosome 9p Status in Renal Cell Carcinoma: A Systematic Review and Quality of the Reported Studies

1Academic Section of Urology, Medical Research Institute, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, UK
2Department of Cytogenetics, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, UK
3Department of Pathology, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, UK
4Division of Imaging and Technology, Medical Research Institute, Medical School, University of Dundee, Dundee DD1 9SY, UK

Received 7 February 2014; Accepted 2 April 2014; Published 30 April 2014

Academic Editor: Paul Crispen

Copyright © 2014 Ismail El-Mokadem et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. H. Weiss and P.-Y. Lin, “Kidney cancer: identification of novel targets for therapy,” Kidney International, vol. 69, no. 2, pp. 224–232, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. N. K. Janzen, H. L. Kim, R. A. Figlin, and A. S. Belldegrun, “Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease,” Urologic Clinics of North America, vol. 30, no. 4, pp. 843–852, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. J. M. Hollingsworth, D. C. Miller, S. Daignault, and B. K. Hollenbeck, “Rising incidence of small renal masses: a need to reassess treatment effect,” Journal of the National Cancer Institute, vol. 98, no. 18, pp. 1331–1334, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Remzi and M. Marberger, “Renal tumor biopsies for evaluation of small renal tumors: why, in whom, and how?” European Urology, vol. 55, pp. 359–367, 2009. View at Google Scholar
  5. P. L. Crispen and R. G. Uzzo, “The natural history of untreated renal masses,” BJU International, vol. 99, no. 5, pp. 1203–1207, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Klatte, J. Patard, M. de Martino et al., “Tumor size does not predict risk of metastatic disease or prognosis of small renal cell carcinomas,” The Journal of Urology, vol. 179, no. 5, pp. 1719–1726, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Junker, G. Weirich, M. B. Amin, P. Moravek, W. Hindermann, and J. Schubert, “Genetic subtyping of renal cell carcinoma by comparative genomic hybridization,” Recent Results in Cancer Research, vol. 162, pp. 169–175, 2003. View at Google Scholar · View at Scopus
  8. E. van den Berg and T. Dijkhuizen, “Classification of renal cell cancer based on (cyto)genetic analysis,” Contributions to Nephrology, vol. 128, pp. 51–61, 1999. View at Google Scholar · View at Scopus
  9. G. Kovacs, L. Fuzesi, A. Emanuel, and H.-F. Kung, “Cytogenetics of papillary renal cell tumors,” Genes Chromosomes and Cancer, vol. 3, no. 4, pp. 249–255, 1991. View at Publisher · View at Google Scholar · View at Scopus
  10. G. Kovacs, M. Akhtar, B. J. Beckwith et al., “The Heidelberg classification of renal cell tumours,” The Journal of Pathology, vol. 183, no. 2, pp. 131–133, 1997. View at Google Scholar · View at Scopus
  11. M. H. Roh, P. dal Cin, S. G. Silverman, and E. S. Cibas, “The application of cytogenetics and fluorescence in situ hybridization to fine-needle aspiration in the diagnosis and subclassification of renal neoplasms,” Cancer Cytopathology, vol. 118, no. 3, pp. 137–145, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. D. A. Barocas, S. Mathew, J. J. DelPizzo et al., “Renal cell carcinoma sub-typing by histopathology and fluorescence in situ hybridization on a needle-biopsy specimen,” BJU International, vol. 99, no. 2, pp. 290–295, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Chyhrai, J. Sanjmyatav, M. Gajda et al., “Multi-colour FISH on preoperative renal tumour biopsies to confirm the diagnosis of uncertain renal masses,” World Journal of Urology, vol. 28, no. 3, pp. 269–274, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Patard, P. Fergelot, P. I. Karakiewicz et al., “Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma,” International Journal of Cancer, vol. 123, no. 2, pp. 395–400, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. B. Grady, R. Goharderakhshan, J. Chang et al., “Frequently deleted loci on chromosome 9 may harbor several tumor suppressor genes in human renal cell carcinoma,” The Journal of Urology, vol. 166, no. 3, pp. 1088–1092, 2001. View at Google Scholar · View at Scopus
  16. T. Klatte, P. N. Rao, M. de Martino et al., “Cytogenetic profile predicts prognosis of patients with clear cell renal cell carcinoma,” Journal of Clinical Oncology, vol. 27, no. 5, pp. 746–753, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Matsuda, S. K. Khoo, A. Massie et al., “Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC,” Cancer Letters, vol. 272, no. 2, pp. 260–267, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Beroukhim, J. Brunet, A. Di Napoli et al., “Patterns of gene expression and copy-number alterations in von-Hippel Lindau disease-associated and sporadic clear cell carcinoma of the kidney,” Cancer Research, vol. 69, no. 11, pp. 4674–4681, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. G. L. Dalgliesh, K. Furge, C. Greenman et al., “Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes,” Nature, vol. 463, no. 7279, pp. 360–363, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. J. C. Strefford, I. Stasevich, T. M. Lane, Y. Lu, T. Oliver, and B. D. Young, “A combination of molecular cytogenetic analyses reveals complex genetic alterations in conventional renal cell carcinoma,” Cancer Genetics and Cytogenetics, vol. 159, no. 1, pp. 1–9, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Kinoshita, H. Yamada, O. Ogawa et al., “Contribution of chromosome 9p21-22 deletion to the progression of human renal cell carcinoma,” Japanese Journal of Cancer Research, vol. 86, no. 9, pp. 795–799, 1995. View at Google Scholar · View at Scopus
  22. H. Bissig, J. Richter, R. Desper et al., “Evaluation of the clonal relationship between primary and metastatic renal cell carcinoma by comparative genomic hybridization,” The American Journal of Pathology, vol. 155, no. 1, pp. 267–274, 1999. View at Google Scholar · View at Scopus
  23. P. Cairns, K. Tokino, Y. Eby, and D. Sidransky, “Localization of tumor suppressor loci on chromosome 9 in primary human renal cell carcinomas,” Cancer Research, vol. 55, no. 2, pp. 224–227, 1995. View at Google Scholar · View at Scopus
  24. J. Dagher, F. Dugay, G. Verhoest et al., “Histologic prognostic factors associated with chromosomal imbalances in a contemporary series of 89 clear cell renal cell carcinomas,” Human Pathology, vol. 44, pp. 2106–2115, 2013. View at Google Scholar
  25. B. Gunawan, W. Huber, M. Holtrup et al., “Prognostic impacts of cytogenetic findings in clear cell renal cell carcinoma: gain of 5q31-qter predicts a distinct clinical phenotype with favorable prognosis,” Cancer Research, vol. 61, no. 21, pp. 7731–7738, 2001. View at Google Scholar · View at Scopus
  26. T. D. Jones, J. N. Eble, and L. Cheng, “Application of molecular diagnostic techniques to renal epithelial neoplasms,” Clinics in Laboratory Medicine, vol. 25, no. 2, pp. 279–303, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Kawada, M. Nakamura, E. Ishida et al., “Aberrations of the p14ARF and p16INK4a genes renal cell carcinomas,” Japanese Journal of Cancer Research, vol. 92, no. 12, pp. 1293–1299, 2001. View at Google Scholar · View at Scopus
  28. D. Schullerus, J. Herbers, J. Chudek, H. Kanamaru, and G. Kovacs, “Loss of heterozygosity at chromosomes 8p, 9p, and 14q is associated with stage and grade of non-papillary renal cell carcinomas,” The Journal of Pathology, vol. 183, pp. 151–155, 1997. View at Google Scholar
  29. J. La Rochelle, T. Klatte, A. Dastane et al., “Chromosome 9p deletions identify an aggressive phenotype of clear cell renal cell carcinoma,” Cancer, vol. 116, no. 20, pp. 4696–4702, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. E. von Elm, D. G. Altman, M. Egger, S. J. Pocock, P. C. Gøtzsche, and J. P. Vandenbroucke, “The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies,” The Lancet, vol. 370, no. 9596, pp. 1453–1457, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Antonelli, N. Arrighi, R. Tardanico et al., “Prognostic value of cytogenetic analysis in clear cell renal carcinoma: a study on 131 patients with long-term follow-up,” Anticancer Research, vol. 30, no. 11, pp. 4705–4709, 2010. View at Google Scholar · View at Scopus
  32. M. Brunelli, A. Eccher, S. Gobbo et al., “Loss of chromosome 9p is an independent prognostic factor in patients with clear cell renal cell carcinoma,” Modern Pathology, vol. 21, no. 1, pp. 1–6, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. B. Gunawan, A. von Heydebreck, T. Fritsch et al., “Cytogenetic and morphologic typing of 58 papillary renal cell carcinomas: evidence for a cytogenetic evolution of type 2 from type 1 tumors,” Cancer Research, vol. 63, no. 19, pp. 6200–6205, 2003. View at Google Scholar · View at Scopus
  34. T. Klatte, A. J. Pantuck, J. W. Said et al., “Cytogenetic and molecular tumor profiling for type 1 and type 2 papillary renal cell carcinoma,” Clinical Cancer Research, vol. 15, no. 4, pp. 1162–1169, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. X. Li, X. Tan, Y. Yu et al., “D9S168 microsatellite alteration predicts a poor prognosis in patients with clear cell renal cell carcinoma and correlates with the down-regulation of protein tyrosine phosphatase receptor delta,” Cancer, vol. 117, no. 18, pp. 4201–4211, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. H. Moch, J. C. Presti Jr., G. Sauter et al., “Genetic aberrations detected by comparative genomic hybridization are associated with clinical outcome in renal cell carcinoma,” Cancer Research, vol. 56, no. 1, pp. 27–30, 1996. View at Google Scholar · View at Scopus
  37. J. C. Presti Jr., M. Wilhelm, V. Reuter, P. Russo, R. Motzer, and F. Waldman, “Allelic loss on chromosomes 8 and 9 correlates with clinical outcome in locally advanced clear cell carcinoma of the kidney,” The Journal of Urology, vol. 167, no. 3, pp. 1464–1468, 2002. View at Google Scholar · View at Scopus
  38. J. Sanjmyatav, K. Junker, S. Matthes et al., “Identification of genomic alterations associated with metastasis and cancer specific survival in clear cell renal cell carcinoma,” The Journal of Urology, vol. 186, no. 5, pp. 2078–2083, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. P. Schraml, K. Struckmann, R. Bednar et al., “CDKN2A mutation analysis, protein expression, and deletion mapping of chromosome 9p conventional clear-cell renal carcinomas: evidence for a second tumor suppressor gene proximal to CDKN2A,” The American Journal of Pathology, vol. 158, no. 2, pp. 593–601, 2001. View at Google Scholar · View at Scopus
  40. P. Schraml, D. Muller, R. Bednar et al., “Allelic loss at the D9S171 locus on chromosome 9p13 is associated with progression of papillary renal cell carcinoma,” The Journal of Pathology, vol. 190, pp. 457–461, 2000. View at Google Scholar
  41. M. I. Toma, M. Grosser, A. Herr et al., “Loss of heterozygosity and copy number abnormality in clear cell renal cell carcinoma discovered by high-density Affymetrix 10K single nucleotide polymorphism mapping array,” Neoplasia, vol. 10, no. 7, pp. 634–642, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. K. Junker, V. Ficarra, E. D. Kwon, B. C. Leibovich, R. H. Thompson, and E. Oosterwijk, “Potential role of genetic markers in the management of kidney cancer,” European Urology, vol. 63, pp. 333–340, 2013. View at Google Scholar
  43. A. O. Receveur, J. Couturier, V. Molinié et al., “Characterization of quantitative chromosomal abnormalities in renal cell carcinomas by interphase four-color fluorescence in situ hybridization,” Cancer Genetics and Cytogenetics, vol. 158, no. 2, pp. 110–118, 2005. View at Publisher · View at Google Scholar · View at Scopus
  44. J. Bayani and J. A. Squire, “Application and interpretation of FISH in biomarker studies,” Cancer Letters, vol. 249, no. 1, pp. 97–109, 2007. View at Publisher · View at Google Scholar · View at Scopus
  45. M. H. T. Bui, D. Seligson, K. Han et al., “Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy,” Clinical Cancer Research, vol. 9, no. 2, pp. 802–811, 2003. View at Google Scholar · View at Scopus
  46. J. Sandlund, E. Oosterwijk, K. Grankvist, J. Oosterwijk-Wakka, B. Ljungberg, and T. Rasmuson, “Prognostic impact of carbonic anhydrase IX expression in human renal cell carcinoma,” BJU International, vol. 100, no. 3, pp. 556–560, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. S. O. Ikuerowo, M. A. Kuczyk, R. von Wasielewski et al., “p16INK4a expression and clinicopathologic parameters in renal cell carcinoma,” European Urology, vol. 51, no. 3, pp. 732–738, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. Y. Kawada, M. Nakamura, E. Ishida et al., “Aberrations of the p14ARF and p16INK4a genes renal cell carcinomas,” Japanese Journal of Cancer Research, vol. 92, no. 12, pp. 1293–1299, 2001. View at Google Scholar · View at Scopus
  49. I. Varela, P. Tarpey, K. Raine et al., “Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma,” Nature, vol. 469, pp. 539–542, 2011. View at Google Scholar
  50. G. Guo, Y. Gui, S. Gao et al., “Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma,” Nature Genetics, vol. 44, no. 1, pp. 17–19, 2012. View at Publisher · View at Google Scholar · View at Scopus