MicroRNA: Important Player in the Pathobiology of Multiple Myeloma

Figure 1

miRNA and IL6-STAT3 signaling in MM. miR-21 is upregulated upon adherence of MM cells to BMSCs. It can be directly induced by STAT3 and contribute to the oncogenic potential of STAT3. At the same time, miR-21 can indirectly induce STAT3 by targeting PIAS3, a STAT3 inhibitor, forming a positive feedback loop. miR-19 has been shown to promote STAT3 signalling by repressing SOCS1. miR-29b could demethylate SOCS1 by targeting DNMTs, leading to upregulation of SOCS1, and negatively regulates IL6-STAT3 signalling.