Therapeutic Potential of Tacrolimus on Acute Myocardial Infarction in Minipigs: Analysis with Serial Cardiac Magnetic Resonance and Changes at Histological and Protein Levels
Figure 1
Cine (a)–(c) and LGE (d)–(f) CMR (in short-axis at midventricular level) of the minipig in the control group on postoperative days 2, 5, and 21 and TTC-stained gross specimen (g). Note the normal anteroseptal LV wall thickness (arrows) on day 2 (a), mild thinning (arrows) on day 5 (b), and further reduction in wall thickness (arrows) and dilated LV chamber on day 21 (c). LGE images demonstrate marked transmural enhancement (arrows) of anteroseptal wall on day 2 (d), persistent transmural enhancement (arrows) on day 5 (e), and further progression of transmural enhancement (arrows) on day 21 (f) with good correlation to gross specimen with extensive transmural infarction (arrows).
