Therapeutic Potential of Tacrolimus on Acute Myocardial Infarction in Minipigs: Analysis with Serial Cardiac Magnetic Resonance and Changes at Histological and Protein Levels
Figure 2
Cine (a)–(c) and LGE (d)–(f) CMR (in short-axis at midventricular level) of the minipig in the tac-treated group on postoperative days 2, 5, and 21 and TTC-stained gross specimen (g). Note the normal anteroseptal LV wall thickness (arrows) on day 2 (a), near normal LV wall (arrows) on day 5 (b), and mild reduction in LV wall thickness (arrows) and normal LV chamber on day 21 (c). LGE images demonstrate marked transmural enhancement (arrows) of anteroseptal wall on day 2 (d), reduced transmural enhancement (arrows) on day 5 (e), and further regression of transmural enhancement (arrows) on day 21 (f) with good correlation to the infarct in gross specimen (arrows).
