Table 2: Comparisons of  left ventricular (LV) function and late gadolinium enhancement (LGE) in AMI minipigs without and with tacrolimus therapy.

Control
Mean ± SD
Tac-treated
Mean ± SD
-value

LV mass/BW ratio (g/kg)
 Day 22.65 ± 0.052.64 ± 0.060.907
 Day 52.62 ± 0.052.62 ± 0.100.848
 Day 212.30 ± 0.062.56 ± 0.050.002
   value (D2 versus D5)0.188 0.438
   value (D2 versus D21)0.031 0.094
   value (D5 versus D21)0.031 0.313
ED volume/BW ratio (mL/kg)
 Day 23.07 ± 0.163.08 ± 0.140.976
 Day 53.23 ± 0.103.19 ± 0.120.167
 Day 213.46 ± 0.143.01 ± 0.110.002
   value (D2 versus D5)0.031 0.156
   value (D2 versus D21)0.031 0.531
   value (D5 versus D21)0.188 0.031
ES volume/BW ratio (mL/kg)
 Day 21.47 ± 0.091.39 ± 0.100.394
 Day 51.77 ± 0.101.54 ± 0.090.006
 Day 212.13 ± 0.181.38 ± 0.140.002
   value (D2 versus D5)0.031 0.063
   value (D2 versus D21)0.031 0.844
   value (D5 versus D21)0.031 0.031
Stroke volume (mL)
 Day 226.72 ± 1.6827.78 ± 1.200.331
 Day 526.08 ± 1.8227.78 ± 0.690.180
 Day 2122.87 ± 1.8629.98 ± 2.770.002
   value (D2 versus D5)0.844 0.563
   value (D2 versus D21)0.031 0.219
   value (D5 versus D21)0.031 0.094
Ejection fraction (%)
 Day 253.00 ± 2.6854.78 ± 2.270.258
 Day 547.13 ± 2.3352.55 ± 1.750.004
 Day 2138.57 ± 3.4654.82 ± 4.690.002
   value (D2 versus D5)0.031 0.156
   value (D2 versus D21)0.031 0.844
   value (D5 versus D21)0.031 0.219
Infarct/LV area on LGE (%)
 Day 214.93 ± 1.2314.84 ± 1.150.967
 Day 515.85 ± 0.8514.15 ± 0.870.013
 Day 2116.75 ± 0.6712.05 ± 0.820.001
   value (D2 versus D5)0.031 0.173
   value (D2 versus D21)0.031 0.031
   value (D5 versus D21)0.031 0.031

BW: body weight; D: post operation day; ED: end diastolic; ES: end systolic; , , values: comparisons between D2 versus D5, D2 versus D21, and D5 versus D21, respectively.
value and values were exact values using Mann-Whitney test* and Wilcoxon signed-rank test, respectively.