Therapeutic Potential of Tacrolimus on Acute Myocardial Infarction in Minipigs: Analysis with Serial Cardiac Magnetic Resonance and Changes at Histological and Protein Levels
Table 2
Comparisons of left ventricular (LV) function and late gadolinium enhancement (LGE) in AMI minipigs without and with tacrolimus therapy.
Control Mean ± SD
Tac-treated Mean ± SD
-value∗
LV mass/BW ratio (g/kg)
Day 2
2.65 ± 0.05
2.64 ± 0.06
0.907
Day 5
2.62 ± 0.05
2.62 ± 0.10
0.848
Day 21
2.30 ± 0.06
2.56 ± 0.05
0.002
value (D2 versus D5)
0.188
0.438
value (D2 versus D21)
0.031
0.094
value (D5 versus D21)
0.031
0.313
ED volume/BW ratio (mL/kg)
Day 2
3.07 ± 0.16
3.08 ± 0.14
0.976
Day 5
3.23 ± 0.10
3.19 ± 0.12
0.167
Day 21
3.46 ± 0.14
3.01 ± 0.11
0.002
value (D2 versus D5)
0.031
0.156
value (D2 versus D21)
0.031
0.531
value (D5 versus D21)
0.188
0.031
ES volume/BW ratio (mL/kg)
Day 2
1.47 ± 0.09
1.39 ± 0.10
0.394
Day 5
1.77 ± 0.10
1.54 ± 0.09
0.006
Day 21
2.13 ± 0.18
1.38 ± 0.14
0.002
value (D2 versus D5)
0.031
0.063
value (D2 versus D21)
0.031
0.844
value (D5 versus D21)
0.031
0.031
Stroke volume (mL)
Day 2
26.72 ± 1.68
27.78 ± 1.20
0.331
Day 5
26.08 ± 1.82
27.78 ± 0.69
0.180
Day 21
22.87 ± 1.86
29.98 ± 2.77
0.002
value (D2 versus D5)
0.844
0.563
value (D2 versus D21)
0.031
0.219
value (D5 versus D21)
0.031
0.094
Ejection fraction (%)
Day 2
53.00 ± 2.68
54.78 ± 2.27
0.258
Day 5
47.13 ± 2.33
52.55 ± 1.75
0.004
Day 21
38.57 ± 3.46
54.82 ± 4.69
0.002
value (D2 versus D5)
0.031
0.156
value (D2 versus D21)
0.031
0.844
value (D5 versus D21)
0.031
0.219
Infarct/LV area on LGE (%)
Day 2
14.93 ± 1.23
14.84 ± 1.15
0.967
Day 5
15.85 ± 0.85
14.15 ± 0.87
0.013
Day 21
16.75 ± 0.67
12.05 ± 0.82
0.001
value (D2 versus D5)
0.031
0.173
value (D2 versus D21)
0.031
0.031
value (D5 versus D21)
0.031
0.031
BW: body weight; D: post operation day; ED: end diastolic; ES: end systolic; , , values: comparisons between D2 versus D5, D2 versus D21, and D5 versus D21, respectively. value∗ and values were exact values using Mann-Whitney test* and Wilcoxon signed-rank test, respectively.
