BioMed Research International / 2014 / Article / Tab 1

Research Article

Synthesis, Characterization and In Vitro Anticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation

Table 1

Inhibition of hybrid molecules (3a–3p) on chronic myeloid leukemia (KBM5) and colon cancer (HCT116) cell lines at 5  M.

CompoundPercentage growth inhibition KBM5Percentage growth inhibition HCT116Activity

3a High
3b High
3c Moderate
3d Moderate
3e Moderate
3f Low
3g Low
3h High
3i Low
3j High
3k High
3l Moderate
3m Low
3n Moderate
3o Low
3p High
Control
Curcumin

Compounds are classified based on potential to inhibit growth of KBM5 cancer cell lines at 5  M, >60%; high activity, >20%; moderate activity, <20%; low activity.

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