Patched Targeting Peptides for Imaging and Treatment of Hedgehog Positive Breast Tumors
Figure 3
Uptake of patched-binding peptides is increased in mammospheres from breast cancer cell lines. (a) Fluorescence microscopy of FITC-labeled peptides A and B in mammospheres from T47-D. (b) Quantification of FITC-peptides A and B uptake in breast cancer cell lines in monolayer and mammosphere cultures. Uptake was significantly higher in cells cultured in mammosphere promoting conditions (3 dimensional cultures) than in those grown in standard monolayer conditions. Significance is represented by asterisk. .
