P-Cresyl Sulfate Is a Valuable Predictor of Clinical Outcomes in Pre-ESRD Patients
Table 3
Univariate and multivariate Cox regression analysis for evaluating the relationship between independent variables and clinical outcomes in CKD patients.
Variables
Cardiovascular event
All-cause mortality
Dialysis
Univariate Cox regression analysis
Multivariate Cox regression analysis
Univariate Cox regression analysis
Univariate Cox regression analysis
Multivariate Cox regression analysis
HR
95% CI
HR
95% CI
HR
95% CI
HR
95% CI
HR
95% CI
Gender (F/M)
0.66
0.24–1.77
NS
0.84
0.12–5.99
NS
0.80
0.29–2.21
NS
Age (years)
1.08
1.01–1.15
0.01
1.12
1.00–1.25
0.01
1.12
0.95–1.30
NS
0.93
0.89–0.98
<0.01
0.91
0.85–0.96
<0.01
CV/Non-CV
2.92
1.01–8.41
0.04
6.28
1.32–29.71
0.02
0.04
0.00–31.81
NS
0.72
0.16–3.19
NS
DM/Non-DM
1.80
0.67–4.83
NS
2.19
0.31–15.58
NS
0.52
0.14–1.84
NS
BUN (mg/dL)
1.03
1.00–1.04
<0.01
0.98
0.95–1.03
NS
0.99
0.94–1.03
NS
1.05
1.02–1.07
<0.01
0.99
0.95–1.03
NS
Cr (mg/dL)
1.11
0.97–1.28
NS
0.89
0.56–1.41
NS
1.51
1.31–1.73
<0.01
1.25
0.74–2.11
NS
eGFR (mL/min)
0.95
0.91–0.99
<0.01
0.99
0.93–1.06
NS
0.98
0.92–1.05
NS
0.80
0.71–0.90
<0.01
0.69
0.47–1.02
NS
Hb (g/dL)
0.85
0.82–1.93
NS
0.79
0.56–1.04
NS
0.85
0.33–2.31
NS
Hct (%)
0.90
0.33–2.42
NS
3.77
0.39–36.31
NS
0.91
0.82–1.01
NS
Albumin (g/dL)
0.82
0.25–2.65
NS
0.85
0.06–10.82
NS
0.39
0.15–0.99
0.04
0.03
0.00–0.33
<0.01
Ca (mg/dL)
0.27
0.11–0.65
<0.01
0.54
0.19–1.54
NS
3.29
0.44–24.11
NS
0.41
0.15–1.10
NS
P (mg/dL)
1.97
1.16–3.33
0.01
1.66
0.70–3.91
NS
0.41
0.08–2.02
NS
2.06
1.15–3.72
0.01
0.93
0.53–1.02
NS
i-PTH (pg/mL)
1.00
1.00-1.00
0.03
1.00
0.99–1.01
NS
1.00
0.99–1.01
NS
1.00
1.00-1.00
<0.01
0.99
0.99-1.00
NS
PCS (mg/L)
1.08
1.02–1.15
<0.01
1.12
1.01–1.21
0.02
1.06
0.94–1.21
NS
1.10
1.02–1.17
<0.01
1.17
1.05–1.30
<0.01
PCS: P-cresyl sulfate, NS: no significance, CI: confidence interval.
