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BioMed Research International
Volume 2014 (2014), Article ID 527029, 10 pages
Review Article

Survey of Network-Based Approaches to Research of Cardiovascular Diseases

Department of Computing, Imperial College London, 180 Queen's Gate, South Kensington Campus, London SW72AZ, UK

Received 26 November 2013; Accepted 7 February 2014; Published 20 March 2014

Academic Editor: Altaf-Ul- Amin

Copyright © 2014 Anida Sarajlić and Nataša Pržulj. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cardiovascular diseases (CVDs) are the leading health problem worldwide. Investigating causes and mechanisms of CVDs calls for an integrative approach that would take into account its complex etiology. Biological networks generated from available data on biomolecular interactions are an excellent platform for understanding interconnectedness of all processes within a living cell, including processes that underlie diseases. Consequently, topology of biological networks has successfully been used for identifying genes, pathways, and modules that govern molecular actions underlying various complex diseases. Here, we review approaches that explore and use relationships between topological properties of biological networks and mechanisms underlying CVDs.