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BioMed Research International
Volume 2014, Article ID 527030, 6 pages
http://dx.doi.org/10.1155/2014/527030
Research Article

Factors Associated with Spontaneous Clearance of Hepatitis C Virus in Chinese Population

1Department of Clinical Epidemiology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China
2Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China
3Key Laboratory of Zoonoses Research, Ministry of Education, 519 Dong Minzhu Street, Changchun, Jilin Province 130021, China
4Department of Infection, Affiliated Hospital of Beihua University, 71 Liberation Road, Jilin City, Jilin Province 132011, China
5Ultrasound Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China
6Section of Hepatology, University of Manitoba, Winnipeg, MB, Canada R3T 2N2
7Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Street, Shanghai 200031, China

Received 13 February 2014; Revised 20 June 2014; Accepted 20 June 2014; Published 16 July 2014

Academic Editor: Mohamed Tarek Shata

Copyright © 2014 Fei Kong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hepatitis C virus (HCV) infections spontaneously clear in approximately 15–45% of infected individuals. Factors which influence spontaneous HCV clearance remain to be identified. The purpose of the present study was to identify variables associated with spontaneous HCV clearance in a referred population of Chinese patients. The prevalence of host, viral, and environmental factors known to influence the outcome of HCV infections was compared in 92 HCV spontaneous clearance subjects and 318 HCV persistent infection subjects. Univariate and multivariate analyses were performed to identify those factors associated with spontaneous HCV clearance. In univariate analysis, female gender, a history of icteric hepatitis, serologic evidence of concurrent HBV infection, and rs12979860 CC genotype were positively associated with spontaneous HCV clearance, while alcohol consumption was negatively associated with clearance. In multivariate analysis, female gender, a history of icteric hepatitis, concurrent HBV infection, and rs12979860 CC genotype remained independent variables associated with spontaneous HCV clearance. Spontaneous HCV clearance is more likely to occur in females, subjects with a history of icteric hepatitis, HBV coinfections, and those with the rs12979860 CC genotype.